Scoliosis in twins. A meta-analysis of the literature and report of six cases

K L Kesling, K A Reinker


This study is a meta-analysis of the world's literature on adolescent idiopathic scoliosis in monozygotic and dizygotic twins. Additionally, six previously unreported cases of scoliosis in twins are presented. To compare and contrast the concordance, severity, and curve patterns in monozygotic and dizygotic twins with adolescent idiopathic scoliosis in an attempt to document a genetic etiology and delineate inheritance patterns for adolescent idiopathic scoliosis. There are numerous case reports of twins sets with adolescent idiopathic scoliosis. However, this data has not been previously analyzed as a single data base. The literature was searched for cases of twins with adolescent idiopathic scoliosis, and six cases of patients treated by authors were added. One hundred cases of sets of twins were discovered, 68 of which had sufficient data for comparative analysis. Each set was evaluated for monozygosity, concordance of scoliosis, curve pattern, and severity of curve. Thirty-seven sets of twins were monozygous, and 31 sets were dizygous. Concordance was 73% among monozygous twins and 36% among dizygous twins. The difference is statistically significant at P < 0.003. Curve severity could be compared in 20 sets of monozygous tw...Continue Reading


Dec 1, 1979·The Journal of Pediatrics·A A SchinzelJ R Miller
Sep 1, 1978·Spine·L M McKinley, K D Leatherman
Feb 1, 1979·Southern Medical Journal·R L Gaertner
Nov 1, 1990·The Journal of Bone and Joint Surgery. British Volume·A J Carr
Mar 1, 1986·The Journal of Bone and Joint Surgery. British Volume·R D Pool
Jul 1, 1972·Clinical Orthopaedics and Related Research·H R CowellG D MacEwen
Dec 1, 1967·Journal of Medical Genetics·F V De George, R L Fisher
Feb 1, 1958·The Journal of Bone and Joint Surgery. British Volume·A H R CODORNIU
Feb 1, 1958·The Journal of Bone and Joint Surgery. British Volume·R ESTEVE
Nov 1, 1959·The Journal of Bone and Joint Surgery. British Volume·G MURDOCH
Jan 1, 1965·The Journal of Pediatrics·B J FOGELP GRUENWALD

❮ Previous
Next ❯


Jan 25, 2003·Spine·Masatoshi InoueHideshige Moriya
Mar 17, 2006·Spine·James W OgilvieKenneth Ward
Apr 6, 2006·American Journal of Medical Genetics. Part a·Nancy H MillerAlexander F Wilson
Apr 12, 2007·Spine·Mikkel O AndersenKirsten O Kyvik
Dec 29, 2007·Journal of Orthopaedic Surgery·G A DayB Brankoff
May 31, 2007·Clinical Orthopaedics and Related Research·Jack C Y ChengNancy Miller
Oct 2, 2008·Neurosurgery·Robert F Heary, Karthik Madhavan
Jan 9, 2009·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Federico ManciniErnesto Ippolito
Mar 1, 2012·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Nelson L S TangJack Chun-Yiu Cheng
Jan 17, 2014·Journal of Children's Orthopaedics·Daniel Studer
Oct 25, 2014·Spine·Tomasz KotwickiMalgorzata Kotwicka
Jun 16, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jiajun ZhangWayne Y W Lee
Aug 31, 1999·Lupus·R D BlankN P Camacho
Dec 21, 2006·Scoliosis·Lucio MontanaroCarla Renata Arciola
Jan 28, 2006·Journal of Pediatric Orthopedics·Robert J BielskiJonathan K Muraskas
Jan 10, 2004·Pediatric Rehabilitation·R G Burwell
Apr 6, 2007·Scoliosis·Theodoros B Grivas, Olga D Savvidou
Jun 27, 2013·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Anna GrauersPaul Gerdhem
Oct 31, 2013·Pediatric Annals·Monique S Burton
Dec 17, 2014·G3 : Genes - Genomes - Genetics·Erin E BaschalNancy H Miller
Mar 11, 2016·International Orthopaedics·Matthew M P Newton Ede, Simon W Jones
Feb 15, 2017·The Journal of Bone and Joint Surgery. American Volume·Kota WatanabeMorio Matsumoto
Jan 1, 2015·Nature Reviews. Disease Primers·Jack C ChengR Geoffrey Burwell
Dec 10, 2016·Scoliosis and Spinal Disorders·A GrauersP Gerdhem
Jul 18, 2017·Human Mutation·Wenjie GaoPeiqiang Su
Apr 11, 2018·Experimental Brain Research·Nikoleta AntoniadouEythimios Samoladas
Nov 22, 2018·Current Opinion in Pediatrics·Ismat Ghanem, Maroun Rizkallah
Jan 12, 2020·BMC Musculoskeletal Disorders·Karolina BorysiakMałgorzata Kotwicka
Aug 23, 2000·The Journal of Bone and Joint Surgery. American Volume·T G LoweC H Rivard
Nov 22, 2001·Clinical Orthopaedics and Related Research·N H MillerA P Wilson

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
R L SepulvedaR U Sorensen
Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology
E J Preston, E Daw
© 2021 Meta ULC. All rights reserved