Scoliosis model created by pedicle screw tethering in immature goats: the feasibility, reliability, and complications

Spine
Yonggang ZhangYan Wang

Abstract

An in vivo model of scoliosis was established in immature goats. To assess the feasibility, reliability, and complications of the innovative animal model. Among the methods of creating a scoliotic model, posterior asymmetric tethering of spine yielded encouraging results. However, some shortcomings associated with the use of posterior asymmetric tether are apparent. Fourteen female goats (age: 5-8 weeks old, weight: 6-8 kg), were instrumented and tethered using unilateral pedicle screws and contralateral rib resections. Twelve of the goats were followed up for 8 weeks by serial radiography. Six goats were removed of the posterior load and no treatment was given. Two goats were selected randomly from the 6 animals and subjected to computed tomography (CT) three-dimensional reconstruction after another 8 weeks. All the 6 goats were killed and spine specimens were harvested for histologic study 16 weeks after observation. Radiographic observation showed that 12 goats developed scoliosis with convex toward the right side, and the curvature increased with time in 11 goats, and it remained unchanged in 1 animal. The angle immediately after the procedures averaged 29.0 degrees (23 degrees -38 degrees ) and increased to an average of 4...Continue Reading

References

Nov 1, 2003·The Spine Journal : Official Journal of the North American Spine Society·Frank P Castro
Sep 3, 2005·Spine·John T BraunJames W Ogilvie
Nov 5, 2005·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Patricia M KallemeierKirkham B Wood

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Citations

May 12, 2011·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Th OdentE Viguier
Oct 27, 2012·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Jean Ouellet, Thierry Odent
Apr 16, 2013·The Spine Journal : Official Journal of the North American Spine Society·Alex K RothLodewijk W van Rhijn
Jul 9, 2013·The Spine Journal : Official Journal of the North American Spine Society·Tom P C SchlösserRené M Castelein
Apr 9, 2011·The Spine Journal : Official Journal of the North American Spine Society·Michiel M A JanssenRené M Castelein
Dec 24, 2014·Clinical Biomechanics·Hans-Joachim WilkeNicolas Graf
Jul 8, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Carl-Éric AubinJeremy Rawlinson
Mar 7, 2018·The Journal of Bone and Joint Surgery. American Volume·Matthew A HalanskiThomas D Crenshaw
Dec 11, 2014·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Justin D BobynAaron Schindeler

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