Scope and limitation of some approaches to predicting contact hypersensitivity

Toxicology in Vitro : an International Journal Published in Association with BIBRA
J J Hostýnek, H I Maibach

Abstract

Allergic contact dermatitis (ACD) is the endpoint of a complex sequence of events. Construction of a predictive computational assay requires a combination of statistical analyses, semi-empirical modelling, chemical acumen and a good understanding of prohapten activation. Main events on the path to the altered self are chemical and microbial conversion on and in the stratum corneum (SC), epidermal penetration, non-specific binding, and finally hapten-protein conjugation. This report reviews the principal approaches currently taken in the prediction of ACD, using computer-based SAR, QSAR and expert systems, and also includes the BIOSAR models, which combine statistical analysis with chemical knowledge. Specifically designed to predict the ACD potential of chemicals in man, the BIOSAR approach of two-value regression analysis achieved a success rate of 88% when trained on a set of 72 compounds of wide diversity, with a sensitivity of 83% and specificity of 100%.

References

Jul 1, 1991·Human & Experimental Toxicology·D M Sanderson, C G Earnshaw
Aug 1, 1991·Journal of Pharmaceutical Sciences·N el TayarA Leo
Dec 1, 1991·The Science of the Total Environment·P S Magee
May 1, 1990·Contact Dermatitis·A S Susten, M J Breitenstein
Jan 1, 1995·Archives of Dermatological Research·J J HostýnekH I Maibach
Mar 1, 1995·Contact Dermatitis·A M Kligman, D A Basketter
Jan 1, 1994·Archives of Dermatological Research·A T KarlbergJ L Nilsson
Apr 1, 1993·International Journal of Epidemiology·H A SmitP J Coenraads
Dec 1, 1995·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·D A BasketterM D Barratt
Feb 17, 1998·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K EnsleinD Bagheri
Nov 9, 2002·Contact Dermatitis·P J FroschI R White
Aug 1, 1997·Toxicology in Vitro : an International Journal Published in Association with BIBRA·J J Hostýnek, P S Magee
Jan 1, 1990·Toxicology in Vitro : an International Journal Published in Association with BIBRA·D W Roberts, D A Basketter

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Citations

Jan 12, 2008·Alternatives to Laboratory Animals : ATLA·Christina GrindonJohn F Garrod
Dec 17, 2008·Alternatives to Laboratory Animals : ATLA·Christina GrindonJohn F Garrod

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