Score on Coma Recovery Scale-Revised at admission predicts outcome at discharge in intensive rehabilitation after severe brain injury

Brain Injury : [BI]
Emilio PortaccioClaudio Macchi

Abstract

To assess the prognostic utility of the Coma Recovery Scale-Revised (CRS-R) in rehabilitation of patients surviving from severe brain injury. In this prospective cohort study, all patients consecutively admitted to an Italian Intensive Rehabilitation Unit, with a diagnosis of unresponsive wakefulness syndrome (UWS) or minimally conscious state (MCS) due to acquired brain injury, underwent clinical evaluations using the Italian version of the CRS-R. At discharge, patients transitioning from UWS to MCS or emergence from MCS (E-MCS) and from MCS to E-MCS were classified as improved responsiveness (IR). Score on the Glasgow Outcome Scale (GOS) at discharge was recorded. In total, 137 (66 UWS, 71 MCS) subjects were enrolled. After a mean hospital stay of 5.3 ± 2.9 months, 81 (59.1%) patients achieved an IR. In the multivariable analysis, IR was associated with higher CRS-R score at admission (p = 0.002) and younger age at injury (p = 0.010). Moreover, higher GOS scores at discharge were related to younger age at injury (p = 0.018), shorter time post-onset (p = 0.003) and higher CRS-R score at admission (p < 0.001). Higher CRS-R scores at admission in intensive rehabilitation unit can help differentiate patients with better outcome a...Continue Reading

References

Mar 1, 1975·Lancet·B Jennett, M Bond
Jun 2, 1994·The New England Journal of Medicine·UNKNOWN Multi-Society Task Force on PVS
Aug 1, 1993·Neurology·N L ChildsH W Childs
Jul 6, 1996·BMJ : British Medical Journal·K AndrewsC Littlewood
Feb 13, 2002·Neurology·Joseph T GiacinoN D Zasler
Dec 18, 2004·Archives of Physical Medicine and Rehabilitation·Joseph T GiacinoJohn Whyte
Apr 14, 2005·Archives of Physical Medicine and Rehabilitation·Michele H LammiChristine M Taylor
Dec 15, 2005·Neuropsychological Rehabilitation·Joseph T Giacino, Kathleen Kalmar
Apr 18, 2006·Lancet·James L Bernat
Jul 1, 2006·Brain Injury : [BI]·Hélène Lefebvre, Marie Josée Levert
Feb 10, 2010·The Journal of Head Trauma Rehabilitation·Marianne LøvstadAnne-Kristine Schanke
Nov 30, 2010·Archives of Physical Medicine and Rehabilitation·UNKNOWN American Congress of Rehabilitation Medicine, Brain Injury-Interdisciplinary Special Interest Group, Disorders of ConsciousnNathan Zasler
Oct 29, 2011·Neurologic Clinics·Ron Hirschberg, Joseph T Giacino
Mar 4, 2015·The Journal of Head Trauma Rehabilitation·Emily McDonnellStephanie A Kolakowsky-Hayner
Mar 31, 2015·Seminars in Neurology·Blessen C EapenDavid X Cifu
Jul 16, 2016·Nature Reviews. Neurology·Tom McMillanMichael Bond
Aug 3, 2016·Acta Neurologica Scandinavica·A GrippoA Amantini

❮ Previous
Next ❯

Citations

Mar 29, 2020·Acta Neurologica Scandinavica·Maenia ScarpinoUNKNOWN Intensive Rehabilitation Unit Study Group of the IRCCS Don Gnocchi Foundation, Italy
Jul 24, 2020·Expert Review of Neurotherapeutics·Caroline Schnakers
Oct 21, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Stefano MasieroAlessandra Del Felice
Oct 27, 2020·Neuropsychological Rehabilitation·Bahia HakikiFrancesca Cecchi
Feb 13, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Sergio BagnatoFrancesca Rubino
Mar 27, 2021·Surgical Neurology International·Jitender ChaturvediBernard R Bendok
Oct 18, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Anna EstraneoLuigi Trojano
Aug 5, 2021·Brain : a Journal of Neurology·Michael J YoungBrian L Edlow

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.