PMID: 18199984Jan 18, 2008Paper

Scoring index for prediction of HER-2 status in the invasive breast carcinoma

Experimental Oncology
K KajoL Plank

Abstract

Detection of HER-2 status represents conditio sine qua non for appropriate therapeutic management of patients with invasive breast carcinoma (IBC). We aimed to modify a DIVER scoring index (sec. Taucher et al., 2003) used for the assessment of HER-2 status probability in IBCs. 660 cases of IBC with determined HER-2, estrogen (ER) and progesterone (PR) receptor status and histologic grade (HG) were included in the study. The HER-2, ER and PR were examined immunohistochemically. Cases showing an HER-2 score of 2+ (n = 38) were further tested by chromogenic in situ hybridisation to confirm or exclude HER-2 gene amplification. Based on the correlation of HER-2 with HG, ER, and PR a score index (HERSI) was designed to set a probability score for evaluation of HER-2 status. This index summarizes the individual score of HG, ER, and PR as follows: HG1 = 2 points, HG2 = 1 point, HG3 = 0 points; a negative ER or PR status = 0 points, a positive ER, or PR status <or= 50% of the cells = 1 point and > 50% of the cells = 2 points. In regard to the final score (0-6 points), cases were divided into subgroups. HER-2 status was positive in 80 cases (12.1%). A statistically significant correlation between HER-2 and HG, ER, PR status was proven (p...Continue Reading

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