Scoring method for identifying patients with Kawasaki disease at high risk of coronary artery aneurysms

The American Journal of Cardiology
H NakanoT Yoshida

Abstract

The beneficial effect of immunoglobulin in preventing coronary artery aneurysms in patients with Kawasaki disease is recognized, but immunoglobulin should be selectively given to patients at high risk for coronary lesions. The present study was designed to present a scoring method to evaluate the severity of Kawasaki disease in terms of coronary artery disease based on clinical and early laboratory findings. Seventy-eight patients who were admitted at 4 to 7 days of illness and who had received aspirin alone during the acute febrile period were separated into 2 groups according to significant coronary artery involvement, and possible related factors to the discrimination of the 2 groups were studied using multivariate analysis. Age at onset, C-reactive protein and platelet count contributed significantly to the discrimination, and from these 3 items a simple scoring system was devised to predict patients at high risk for coronary lesions. Retrospective study using this scoring method indicated that significant coronary artery disease was more often seen in patients predicted to be at high risk treated with aspirin, while no patients who received immunoglobulin had coronary lesions of moderate or severe degree. Thus, the present...Continue Reading

References

Nov 15, 1985·The American Journal of Cardiology·H NakanoK Nojima

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Citations

Aug 4, 2005·Indian Journal of Pediatrics·Monesha Gupta-Malhotra, P Syamasundar Rao
Dec 24, 2005·Pediatric Cardiology·H MutaT Matsuishi
Sep 10, 2005·Journal of Paediatrics and Child Health·Davinder Singh-GrewalDavid Isaacs
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May 27, 2014·Pediatric Cardiology·Qiu-Qin XuWen-Hua Yan
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Mar 2, 2016·International Journal of Molecular Sciences·Donato RiganteSusanna Esposito
Jun 20, 2007·Circulation·Brian W McCrindleUNKNOWN Pediatric Heart Network Investigators
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Aug 1, 1991·Scottish Medical Journal·F S Odaibo, K M Goel
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