Scoring the tumor-stroma ratio in colon cancer: procedure and recommendations

Virchows Archiv : an International Journal of Pathology
Gabi W van PeltW E Mesker

Abstract

The tumor-stroma ratio (TSR) has been reported as a strong, independent prognostic parameter in colon cancer as well as in other epithelial cancer types, and may be implemented to routine pathology diagnostics. The TSR is an easy technique, based on routine hematoxylin and eosin stained histological sections, estimating the amount of stroma present in the primary tumor. It links tumors with high stromal content to poor prognosis. The analysis time is less than 2 min with a low inter-observer variation. Scoring of the TSR has been validated in a number of independent international studies. In this manuscript, we provide a detailed technical description of estimating the TSR in colon cancer, including examples, pitfalls, and recommendations.

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Citations

Nov 24, 2018·Science·Tomasz Sulej, Grzegorz Niedźwiedzki
Sep 20, 2019·Breast Cancer Research and Treatment·Kiki M H VangangeltWilma E Mesker
Jan 5, 2020·International Journal of Cancer. Journal International Du Cancer·Kiki M H VangangeltWilma E Mesker
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Sep 22, 2020·Virchows Archiv : an International Journal of Pathology·Alhadi AlmangushIlmo Leivo
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Feb 23, 2020·Virchows Archiv : an International Journal of Pathology·Benedikt MartinBruno Märkl
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Dec 16, 2020·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Ibrahim O BelloTuula Salo
Jan 1, 2021·Cancers·Allison A FitzgeraldLouis M Weiner
Feb 11, 2021·United European Gastroenterology Journal·Hao DangUNKNOWN Dutch T1 CRC Working Group
Mar 7, 2021·International Journal of Molecular Sciences·Maria TabusoRamesh Pulendran Arasaradnam
Nov 30, 2020·Cancer Treatment and Research Communications·Marloes A SmitWilma E Mesker
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Jun 3, 2021·Journal of Clinical Medicine·Ana CaruntuOana Cristina Voinea
Sep 18, 2021·International Journal of Colorectal Disease·Marloes A SmitJ Han J M van Krieken
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Jan 23, 2022·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·M T A StrousA P de Bruïne

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Methods Mentioned

BETA
biopsies
biopsy

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