Scorpion venom leads to gastrointestinal ischemia despite increased oxygen delivery in pigs

Critical Care Medicine
S SoferS M Scharf

Abstract

Scorpion envenomation may be accompanied by metabolic acidosis even in the absence of hypoxia and cardiovascular derangement. We tested the hypothesis that venom causes ischemia of the gastrointestinal tract rather than failure of delivery of oxygen to the periphery. Repeated measures, prospective study in experimental animals. University-affiliated hospital research laboratory. In ten spontaneously breathing, intubated, sedated pigs, purified dried venom (Leiurus quinquestriatus), 0.05 mg/kg, was administered intravenously. Measurements were obtained before (baseline), and 5, 15, 30, 60, 120, 180, and 240 mins after injection. Variables measured included: mean arterial pressure (MAP), heart rate (HR), mean pulmonary arterial pressure, pulmonary artery occlusion pressure, cardiac output, stroke volume, right ventricular ejection fraction (rapid thermistor), left ventricular dimensions (echocardiography), arterial gas tensions, lactate and catecholamine concentrations, gastric interstitial mucosal pH (tonometry), as well as systemic and pulmonary vascular resistances. Within 5 mins after venom injection, there was a hyperdynamic state accompanied by significantly increased MAP (97 +/- 18 to 136 +/- 47 mm Hg, p < .0003), HR (70 +...Continue Reading

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Citations

Mar 19, 2013·Toxicon : Official Journal of the International Society on Toxinology·Shaul SoferTamar Bernstein
Aug 2, 2003·Toxicon : Official Journal of the International Society on Toxinology·Ariel TarasiukShaul Sofer
Aug 5, 1998·Toxicon : Official Journal of the International Society on Toxinology·A TarasiukS Sofer
Jul 20, 2002·Critical Care Medicine·Steven M Scharf
Oct 19, 2000·Journal of Basic and Clinical Physiology and Pharmacology·A TarasiukS Sofer
Jun 17, 2004·Journal of Basic and Clinical Physiology and Pharmacology·Ariel TarasiukShaul Sofer
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Oct 22, 2008·Toxicon : Official Journal of the International Society on Toxinology·Mounir BouazizNoureddine Rekik
Jan 27, 2006·Gastroentérologie Clinique Et Biologique·Mabrouk BahloulMounir Bouaziz
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Aug 14, 2019·The American Journal of Tropical Medicine and Hygiene·Khaled A Baseer, Mohamed A A Naser
Feb 6, 2007·Annals of Saudi Medicine·G Gajre, A S Dammas

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