Scotoma size reduction as an adaptive strategy in age-related macular degeneration

Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
Kevin K Lee, Samuel N Markowitz

Abstract

Retinal areas with reduced sensitivity to light stimuli represent the true scotoma size in patients with age-related macular degeneration (AMD), whereas the perceived visual field defect area that covers a specific target of regard may represent an effective size of the same scotoma. This study was designed to highlight the conceptual difference between the "true scotoma size" and its "effective scotoma size" counterpart. Prospective nonrandomized observational case series. Ten adults with documented AMD, low vision, and best-corrected visual acuity of 20/50-20/200 in the better eye. Effective scotoma size and true scotoma size were calculated from measurements with the macular grid test performed with automated perimetry and from microperimetry performed with the Nidek MP-1, respectively. Ten patients aged 70-92 years (mean 81 years) met the inclusion criteria. Mean effective scotoma size measured with the macular grid test was 40.19 (SD 34.88) deg2. Mean true scotoma size measured with microperimetry was 75.17 (SD 56.08) deg2 (p < or = 0.003). The log unit change in scotoma size, defined as scotoma utility score, was -55.91%. The effect size observed for the scotoma utility score was 0.74. Effective scotoma size experienced b...Continue Reading

References

Jul 1, 1982·American Journal of Ophthalmology·F L FerrisI Bailey
Jun 1, 1993·Archives of Ophthalmology·R A Schuchard
Jul 1, 1995·Ophthalmology·J B Jonas, K Papastathopoulos
Dec 5, 2002·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Michael D Crossland, Gary S Rubin
Aug 21, 2003·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Salomon Yves CohenJean-François LeGargasson
Mar 26, 2004·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Samuel N Markowitz, Charlene Muller
Apr 14, 2004·Archives of Ophthalmology·David S FriedmanUNKNOWN Eye Diseases Prevalence Research Group
Mar 16, 2005·Optometry and Vision Science : Official Publication of the American Academy of Optometry·George T TimberlakeJoseph H Maino
Dec 31, 2005·Investigative Ophthalmology & Visual Science·Peter E Pidcoe, Paul A Wetzel
Jun 13, 2006·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Rani Al-Karmi, Samuel N Markowitz
Sep 28, 2007·Investigative Ophthalmology & Visual Science·Esther G GonzálezMartin J Steinbach

❮ Previous
Next ❯

Citations

Oct 8, 2013·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Lucía Martínez-CostaPilar Marco-Ventura
Feb 5, 2010·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Samuel N Markowitz, Natalya Aleykina
Dec 22, 2017·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Essam S AlmutlebShirin E Hassan
Jul 18, 2020·Restorative Neurology and Neuroscience·Paul LénéAarlenne Zein Khan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.