Scotopic sensitivity in schizophrenia

Schizophrenia Research
Audrey H GutherieBilly R Hammond

Abstract

Among participants with schizophrenia there is evidence for early-stage visual processing deficits, which may arise in the rod pathways. Input to the earliest level of this pathway, however, has not been tested in this population. It has been widely hypothesized that schizophrenia participants have magnocellular deficits that occur at the pre-cortical level. To address this hypothesis, we studied absolute scotopic (dark-adapted) sensitivity in fifteen schizophrenia and fifteen matched control participants. Scotopic thresholds were assessed using a 1.85-deg, 510-nm circular test stimulus located at 10 degrees eccentricity in the left visual field and presented in Maxwellian-view. Thresholds were obtained using a two-alternative forced-choice paradigm (an average of 200 trials per participant was obtained). Threshold estimates were derived using probit analysis. In this procedure the transformed binomial data (the inverse of the normal probability integral) is fit with a weighted linear regression. Noise was defined as the average deviation from this line. Lens optical density was also assessed by comparing absolute scotopic thresholds to the extinction spectrum of rhodopsin. Scotopic thresholds and lens density values of the two...Continue Reading

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Citations

Feb 1, 2012·Acta Neuropsychiatrica·Bernt C Skottun, John R Skoyles
Mar 11, 2009·Psychiatry Research·Jeffrey S BedwellScott R Sutterby
Oct 22, 2013·Vision Research·Neda Khosravani, Mohammad Ali Goodarzi
Mar 17, 2015·Current Psychiatry Reports·Carolina P B GracitelliFelipe A Medeiros
Feb 2, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jeffrey S BedwellYuri Rassovsky
Sep 11, 2007·Vision Research·Bernt C Skottun, John R Skoyles

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