Screening a repurposing library, the Medicines for Malaria Venture Stasis Box, against Schistosoma mansoni

Parasites & Vectors
Valérian PascheJennifer Keiser

Abstract

The development of new treatments against schistosomiasis is imperative but lacks commercial interest. Drug repurposing represents a suitable strategy to identify potential treatments, which have already unblocked several essential steps along the drug development path, hence reducing costs and timelines. Promoting this approach, the Medicines for Malaria Venture (MMV) recently distributed a drug repurposing library of 400 advanced lead candidates (Stasis Box). All 400 compounds were initially tested in vitro against the larval stage of Schistosoma mansoni at 10 μM. Hits progressed to screening on adult worms and were further characterised for IC50, cytotoxicity and selectivity. Ten lead compounds were tested in mice harbouring a chronic S. mansoni infection. Eleven of the 37 compounds active on the larval stage were also highly active on adult worms in vitro (IC50 = 2.0-7.5 μM). IC50 values on adult S. mansoni decreased substantially in the presence of albumin (7.5-123.5 μM). Toxicity to L6 and MRC cells was moderate. A moderate worm burden reduction of 51.6% was observed for MMV690534, while the other 9 compounds showed low activity. None of the in vivo results were statistically significant (P > 0.05). Phenotypic screening o...Continue Reading

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Citations

Jan 4, 2019·Antimicrobial Agents and Chemotherapy·Claudia MachicadoLuis A Marcos
Oct 24, 2019·Parasites & Vectors·Martina MaccesiConor R Caffrey
Jan 23, 2021·RSC Medicinal Chemistry·Godwin Akpeko DziwornuKelly Chibale
May 26, 2021·PLoS Neglected Tropical Diseases·Nermina VejzagićClarissa Prazeres da Costa
Oct 7, 2021·Expert Review of Anti-infective Therapy·Stefan BiendlJennifer Keiser

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Methods Mentioned

BETA
FCS

Software Mentioned

Softmax
R
CompuSyn2

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