Screening and advanced lipid phenotyping in familial hypercholesterolemia: The Very Large Database of Lipids Study-17 (VLDL-17)

Journal of Clinical Lipidology
P Elliott MillerSteven R Jones

Abstract

Familial hypercholesterolemia (FH) is an autosomal dominant dyslipidemia characterized by defective low-density lipoprotein (LDL) clearance. The aim of this study was to compare Friedewald-estimated LDL cholesterol (LDL-C) to biologic LDL-C in individuals screening positive for FH and then further characterize FH phenotypes. We studied 1,320,581 individuals from the Very Large Database of Lipids, referred from 2009 to 2011 for Vertical Auto Profile ultracentrifugation testing. Friedewald LDL-C was defined as the cholesterol content of LDL-C, intermediate-density lipoprotein cholesterol, and lipoprotein(a) cholesterol (Lp(a)-C), with LDL-C representing biologic LDL-C. Using Friedewald LDL-C, we phenotypically categorized patients by the National Lipid Association guideline age-based screening thresholds for FH. In those meeting criteria, we categorized patients using population percentile-equivalent biologic LDL-C cutpoints and explored Lp(a)-C and remnant lipoprotein cholesterol (RLP-C) levels. Overall, 3829 patients met phenotypic criteria for FH by Friedewald LDL-C screening (FH+). Of those screening FH+, 78.8% were above and 21.2% were below the population percentile-equivalent biologic LDL-C. The mean difference in Friedewa...Continue Reading

Associated Clinical Trials

References

Aug 15, 2002·Circulation·Pernette R W de Sauvage NoltingUNKNOWN Examination of Probands and Relatives in Statin Studies with Familial Hypercholesterolemia (ExPRESS) Study Group
Mar 1, 1965·Circulation·D S FREDRICKSON, R S LEES
Jun 5, 2004·Atherosclerosis·Fernando Civeira, UNKNOWN International Panel on Management of Familial Hypercholesterolemia
Nov 18, 2006·Clinics in Laboratory Medicine·Krishnaji R Kulkarni
Nov 13, 2008·BMJ : British Medical Journal·Jorie VersmissenEric J G Sijbrands
Mar 24, 2011·JAMA : the Journal of the American Medical Association·Cynthia A JackeviciusHarlan M Krumholz
May 27, 2011·Journal of Clinical Lipidology·Paul N HopkinsUNKNOWN National Lipid Association Expert Panel on Familial Hypercholesterolemia
Feb 5, 2013·Journal of the American College of Cardiology·Pia R KamstrupBørge G Nordestgaard
Oct 15, 2013·Clinical Cardiology·Seth S MartinSteven R Jones
Mar 19, 2014·Journal of Clinical Lipidology·Gerald F WattsJohn J P Kastelein
Apr 29, 2014·American Heart Journal·Lingyun LuCynthia A Jackevicius
Nov 19, 2014·Current Atherosclerosis Reports·David I FeldmanSeth S Martin

❮ Previous
Next ❯

Citations

May 8, 2016·The American Journal of Medicine·Catherine S BennetJohn W McEvoy
Jun 5, 2016·Mayo Clinic Proceedings·Maya S Safarova, Iftikhar J Kullo
Apr 15, 2016·Journal of Lipid Research·Konrad SchmidtGerd Utermann
Dec 9, 2017·Nature Reviews. Disease Primers·Joep C DefescheAnthony S Wierzbicki
Oct 28, 2019·Journal of Atherosclerosis and Thrombosis·Mariko Harada-Shiba
Feb 24, 2016·Journal of Atherosclerosis and Thrombosis·Jing PangGerald F Watts
Jan 19, 2016·Current Opinion in Lipidology·Anthony S Wierzbicki, Gerald F Watts
Jun 21, 2021·Current Atherosclerosis Reports·Anne Langsted, Børge G Nordestgaard

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.