Screening and discovery of lineage-specific mitosomal membrane proteins in Entamoeba histolytica

Molecular and Biochemical Parasitology
Herbert J SantosTomoyoshi Nozaki

Abstract

Entamoeba histolytica, an anaerobic intestinal parasite causing dysentery and extra-intestinal abscesses in humans, possesses highly reduced and divergent mitochondrion-related organelles (MROs) called mitosomes. This organelle lacks many features associated with canonical aerobic mitochondria and even other MROs such as hydrogenosomes. The Entamoeba mitosome has been found to have a compartmentalized sulfate activation pathway, which was recently implicated to have a role in amebic stage conversion. It also features a unique shuttle system via Tom60, which delivers proteins from the cytosol to the mitosome. In addition, only Entamoeba mitosomes possess a novel subclass of β-barrel outer membrane protein called MBOMP30. With the discoveries of such unique features of mitosomes of Entamoeba, there still remain a number of significant unanswered issues pertaining to this organelle. Particularly, the present understanding of the inner mitosomal membrane of Entamoeba is extremely limited. So far, only a few homologs for transporters of various substrates have been confirmed, while the components of the protein translocation complexes appear to be absent or are yet to be discovered. Employing a similar strategy as in our previous wo...Continue Reading

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Citations

Dec 30, 2017·BMC Genomics·Małgorzata WojtkowskaHanna Kmita
Sep 12, 2018·Trends in Parasitology·Herbert J SantosTomoyoshi Nozaki
May 3, 2021·Parasitology International·Herbert J Santos, Tomoyoshi Nozaki
Nov 16, 2021·PLoS Pathogens·Zdeněk VernerJan Tachezy

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