Screening Circulating Tumor Cells as a Noninvasive Cancer Test in 3388 Individuals from High-Risk Groups (ICELLATE2)

Disease Markers
Juan CastroChrister Ericsson

Abstract

Cancer is known to spread up to 12 years before clinical symptoms occur, but few screening tests exist. Early detection would give the opportunity for early treatment, potentially improving prognosis. To this end, 3388 subjectively healthy individuals of age 45 to 80 who had been exposed to cancer risk factors were screened for the occurrence of circulating tumor cells in their blood. Presence of circulating tumor cells is a suspicious finding indicative of spreading cancer, since cancer metastasizes by way of the blood and offers the opportunities to (a) follow up the individual clinically based on established guidelines for early detection of cancer and (b) evaluate the cells further analytically. 107 individuals showed one or more circulating tumor cells in a 7.5 ml blood sample, which constitutes a positive circulating tumor cell test, based on the iCellate IsoPic™ laboratory test. That number compares favorably with the cancer incidence per 100,000 people/year that is 157.1 in Peru, given that a high-risk group of individuals was screened and that the screening results would be expected to correspond to an accumulated incidence of up to 12 years. The present findings therefore identify screening for circulating tumor cells...Continue Reading

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Citations

Dec 8, 2019·Clinical Chemistry·Luis Enrique Cortés-HernándezCatherine Alix-Panabières
Apr 3, 2020·Diagnostics·Leonie KonczallaMatthias Reeh
Sep 25, 2019·Cold Spring Harbor Perspectives in Medicine·Zahra Eslami-SCatherine Alix-Panabières
Jan 27, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Sai Shyam VasantharajanAniruddha Chatterjee
May 8, 2021·Clinical & Experimental Metastasis·Catherine Alix-PanabieresJane L Messina
Aug 8, 2021·Cancers·Elisa DamaFabrizio Bianchi

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Methods Mentioned

BETA
blood draw

Software Mentioned

CellSearch
NIS
Elements Advanced Research
ICELLATE2
IsoPic

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