Screening coagulation testing using the APTT: which reagent to choose?

American Journal of Hematology
Francine R DembitzerEllinor I B Peerschke

Abstract

APTT testing is integral to hemostasis testing. A prolonged result, however, can be difficult to interpret, depending on the APTT reagent's sensitivity to the lupus anticoagulant. This often generates additional laboratory testing for both factor deficiencies and the presence of a lupus anticoagulant, and in so doing, delays patient management. We have found it useful to provide APTT testing with both a lupus anticoagulant sensitive and insensitive reagent, to facilitate the rapid exclusion of significant factor deficiencies. The following case report illustrates the utility of this approach and provides a backdrop for necessary discussions between laboratories and clinicians regarding which APTT reagent best meets their clinical need for screening hemostasis testing.

Citations

Jul 4, 2013·Southern Medical Journal·Pramod Reddy
Mar 31, 2012·Haemophilia : the Official Journal of the World Federation of Hemophilia·M SahudJ Dlott
May 18, 2016·International Journal of Laboratory Hematology·P ToulonA Appert-Flory
Dec 2, 2016·Antibodies·Gary W Moore

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