Screening detects a high proportion of celiac disease in young HLA-genotyped children

Journal of Pediatric Gastroenterology and Nutrition
Sara BjörckDaniel Agardh

Abstract

Celiac disease is associated with tissue transglutaminase autoantibodies (tTGAb) and the human leukocyte antigen (HLA)-risk alleles DQB1*02 and DQB1*0302. The aim was to estimate the proportion of undiagnosed celiac disease in children with HLA risk at 3 years of age. From a population-based HLA-DQ screening study of newborns born between June 2001 and August 2004 in the southern part of Sweden, 6206 children with HLA-risk alleles were identified and asked to participate at a mean 3.3 +/- 0.4 years of age. As controls, 7654 children with HLA-nonrisk alleles were asked to participate. In all, 1620 (26.1%) children with HLA risk and 1815 (23.7%) controls were screened for tTGAb using radioligand-binding assays. Celiac disease was established by intestinal biopsy in children with a confirmed positive tTGAb test. Twenty-three children reported already having clinically diagnosed celiac disease and did not participate further. In children with HLA-risk genotypes, 73 of 1620 (4.5%, 95% CI 3.5%-5.5%) were tTGAb-positive compared with none of 1815 from the controls (P < 0.0001). Seventy-one children underwent biopsy (1 refused biopsy and 1 biopsy failed), of whom 56 of 1618 (3.5%, 95% CI 2.6%-4.4%) had damaged intestinal mucosa classif...Continue Reading

References

Sep 1, 1990·Archives of Disease in Childhood·J A Walker-Smith
Jul 3, 1998·Gastroenterology·J S Trier
Dec 3, 1998·Gastroenterology·W DieterichD Schuppan
Nov 5, 1999·Digestive Diseases·P CollinM Mäki
Apr 30, 2002·Best Practice & Research. Clinical Gastroenterology·Hugh FreemanPierre Pare
May 16, 2002·Journal of Medical Genetics·S PopatR S Houlston
Jun 20, 2003·The New England Journal of Medicine·Markku MäkiMikael Knip
May 25, 2004·Archives of Disease in Childhood·A TommasiniA Ventura
Dec 17, 2004·Pediatric Diabetes·Barbro LernmarkSture Sjöblad
Jul 2, 2005·Diabetologia·H E LarssonUNKNOWN DiPiS Study Group
Apr 28, 2006·Scandinavian Journal of Gastroenterology·Annelie CarlssonSten-A Ivarsson
Nov 22, 2007·Journal of Pediatric Gastroenterology and Nutrition·Andrea GarampazziGiuseppina Oderda
Feb 6, 2008·Archives of Pediatrics & Adolescent Medicine·Grzegorz TelegaSteven Werlin

❮ Previous
Next ❯

Citations

Apr 27, 2012·Seminars in Immunopathology·Shuo-Wang QiaoLudvig M Sollid
Mar 16, 2013·Nature Reviews. Immunology·Ludvig M Sollid, Bana Jabri
Nov 17, 2012·World Journal of Gastroenterology : WJG·Naiyana GujralAlan B R Thomson
Jan 12, 2011·Annual Review of Immunology·Valérie AbadieBana Jabri
Jan 12, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ewa H LavantJoyce A Carlson
Nov 26, 2015·Seminars in Immunology·J Stamnaes, L M Sollid
Mar 13, 2016·Autoimmunity Reviews·Pierre-André Jarrot, Gilles Kaplanski
Sep 13, 2014·Current Opinion in Immunology·Ludvig M SollidKai W Wucherpfennig
Jun 11, 2015·Best Practice & Research. Clinical Gastroenterology·M Fleur du Pré, Ludvig M Sollid
Sep 23, 2014·Critical Reviews in Clinical Laboratory Sciences·Vilte E BarakauskasMathew P Estey
Jan 28, 2015·Gastroenterology·Jeroen van BergenFrits Koning
Jul 28, 2016·Mucosal Immunology·J Spencer, L M Sollid
Mar 21, 2017·Journal of Pediatric Gastroenterology and Nutrition·Sara BjörckDaniel Agardh
May 20, 2011·Journal of Pediatric Gastroenterology and Nutrition·Haude Clouzeau-GirardThierry Lamireau
Jul 28, 2010·Journal of Pediatric Gastroenterology and Nutrition·Enrico VallettaMartina Fornaro
Jun 13, 2019·International Journal of Immunogenetics·Dimitri PoddigheGian Luigi Marseglia
Oct 21, 2015·Journal of Pediatric Gastroenterology and Nutrition·María Luz CillerueloCarmen Hernando de Larramendi
Oct 16, 2015·Journal of Pediatric Gastroenterology and Nutrition·Sara Björck, Daniel Agardh
May 15, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Omri SnirLudvig M Sollid
Jun 18, 2020·Frontiers in Nutrition·Mariantonia Maglio, Riccardo Troncone
Aug 25, 2015·Journal of Pediatric Gastroenterology and Nutrition·Sara BjörckDaniel Agardh
Jul 18, 2018·Clinical Rheumatology·Francesco CasoFabiola Atzeni
Feb 16, 2019·Journal of Clinical Medicine·Elena LionettiUNKNOWN SIGENP Working Group of Weaning and CD Risk
Nov 16, 2019·The Journal of Experimental Medicine·M Fleur du PréLudvig M Sollid
Oct 24, 2020·HLA : Immune Response Genetics·Adugna N GudetaDaniel Agardh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved