Screening, diagnosis, and treatment of dyslipidemia among persons with persistent mental illness: a literature review

Psychiatric Services : a Journal of the American Psychiatric Association
Erik R VanderlipWilliam G Haynes

Abstract

Cardiovascular disease is the most frequent cause of death of persons with severe and persistent mental illness, and there is evidence of a widening mortality gap with the general population. Modifiable risk factors for cardiovascular disease, including dyslipidemia, are frequently underrecognized and undertreated. This review provides practitioners with an update on screening, diagnosis, and referral or treatment of dyslipidemia in this population. A literature search in PubMed from 1990 to 2012 that used various combinations of the terms cholesterol, screening, diagnosis, treatment, and severe mental illnesses identified 74 clinically relevant articles for review, and reference lists guided further exploration of sources. Additional material was selected with a focus on emerging guidelines to create clinically relevant recommendations for practitioners. Multiple barriers can prevent clinicians from obtaining samples from fasting patients, which can be detrimental to successful screening. Dyslipidemia can be successfully screened for with nonfasting total cholesterol, high-density lipoprotein (HDL) cholesterol, and triglycerides, with follow-up measurement of fasting low-density lipoprotein (LDL) cholesterol if total cholester...Continue Reading

Citations

Aug 25, 2015·The Psychiatric Clinics of North America·Robert M McCarron
May 7, 2016·Journal of General Internal Medicine·Christina MangurianDean Schillinger
Jan 11, 2018·Hormone Molecular Biology and Clinical Investigation·Oluchi AbosiJess G Fiedorowicz
Mar 2, 2019·International Review of Psychiatry·Lauren R PudalovMarsha Wittink
Apr 1, 2019·Heart and Mind·Jonathan W BirdsallJess G Fiedorowicz

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