Screening differential circular RNA expression profiles reveal that hsa_circ_0128298 is a biomarker in the diagnosis and prognosis of hepatocellular carcinoma

Cancer Management and Research
Dawei ChenHaiyong Wang

Abstract

The aim of this study was to analyze the diagnostic and prognostic values of the circular RNA (circRNA) hsa_circ_0128298 in hepatocellular carcinoma (HCC). The global circRNA expression was measured using circRNA microarray using three pairs of cancer and noncancerous tissues from HCC patients. The microarray analysis revealed that two circRNAs were differentially expressed in the three pairs of cancerous and noncancerous tissues. The higher levels of two representative circRNAs, such as hsa_circ_0128298 and hsa_circ_0091582, were further confirmed by real-time polymerase chain reaction. In addition, the association between the expression level of hsa_circ_0128298 and the clinicopathological features of patients with HCC was further analyzed. The clinical diagnosis value was confirmed by receiver operating characteristic (ROC) curve analysis. Independent prognostic factors of patient outcome were identified using the Cox regression model. The survival data were analyzed by the Kaplan-Meier method, and the differences were evaluated using log-rank tests. Two-sided P-values <0.05 were considered statistically significant. The expression levels of hsa_circ_0128298 in HCC were significantly higher than those of paratumorous tissues...Continue Reading

Citations

Nov 10, 2018·Current Gene Therapy·Shuai FangZhaohui Gong
Apr 14, 2020·Journal of Cellular and Molecular Medicine·Jin-Yu SunXiao-Xin Mu
May 8, 2020·International Journal of Oncology·Hao-Ying WangYong-Ning Zhou
Oct 31, 2019·World Journal of Gastrointestinal Oncology·Ya-Lin JiangYong-Chao Chang
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Methods Mentioned

BETA
surgical resection

Software Mentioned

R
Graph
Statistical Product and Service Solutions ( SPSS )
- Pad Prism
GraphPad

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