Screening Europe 2010: an update about the latest technologies and applications in high-throughput screening

Expert Review of Molecular Diagnostics
Christoph A Merten

Abstract

This article reviews important presentations from the 7th Screening Europe Conference, and extracts general trends and developments. Technological advances, as well as novel applications are discussed, thus providing an overview on state-of-the-art high-throughput screening. Among other topics, cell-based assays were highly popular, since they reflect the clinical situation much more closely than screens based on purified drug targets. A further approach to reduce the costly attrition of drug candidates subsequent to initial screens is the use of label-free technology. By measuring desired properties directly, without the use of any reporter (e.g., calorimetric measurements of binding affinities), the selection of false positives can be decreased drastically. Additional improvements in high-throughput screening are resulting from novel technology platforms utilizing sophisticated imaging systems and/or miniaturization. These and other important topics from the Screening Europe 2010 Conference are discussed in this article, thus providing a current snapshot of the field.

References

May 17, 2003·Nature Reviews. Drug Discovery·Konrad H BleicherAlexander I Alanine
Jun 3, 2005·The Journal of Biological Chemistry·Andrew K P TaggartM Gerard Waters
Jan 10, 2008·Nature Biotechnology·Mazen W KaramanPatrick P Zarrinkar
Aug 13, 2008·Combinatorial Chemistry & High Throughput Screening·Richard M EglenTerry Reisine
Apr 8, 2009·The Journal of Clinical Investigation·Robert W WaltersRobert J Lefkowitz
Apr 30, 2009·The Journal of Antimicrobial Chemotherapy·Lucia GranieriChristoph A Merten
Jul 2, 2009·Nature Reviews. Drug Discovery·Yan FengJohn A Tallarico
Jul 17, 2009·The Journal of Biological Chemistry·L Sangeetha VedulaPatrick J Loll
Dec 17, 2009·Journal of Biomolecular Screening·Zurab SurviladzeLarry A Sklar
Feb 17, 2010·Combinatorial Chemistry & High Throughput Screening·Jenifer Clausell-TormosChristoph A Merten
Mar 27, 2010·Chemistry & Biology·Lucia GranieriChristoph A Merten
May 7, 2010·Lab on a Chip·Jenifer Clausell-TormosChristoph A Merten

❮ Previous
Next ❯

Citations

Apr 4, 2012·Expert Opinion on Drug Discovery·Reena Halai, Matthew A Cooper
Nov 16, 2012·The Journal of Physical Chemistry. B·Saroj KumarAndreas Barth

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.