Screening for autism spectrum disorder in very preterm infants during early childhood

Early Human Development
P H GrayKristen Gibbons

Abstract

The aim of the study was to screen very preterm infants for autism spectrum disorder (ASD) with comparisons to a group of term controls. The study also aimed to identify maternal and neonatal risk factors, development and behaviour associated with a positive screen in the preterm group. Preterm infants born ≤ 30 weeks gestation and term infants were recruited at two years of age. The mothers were posted the questionnaires and completed the Modified Checklist for Autism in Toddlers (M-CHAT), the Child Behaviour Checklist (CBCL) and the Depression, Anxiety and Stress Scales (DASS). Previously collected data from the mothers at 12 months--the Edinburgh Postnatal Depression Scales (EPDS) were analysed. The children had neurodevelopmental assessment including the Bayley-III. Infants positive on M-CHAT screen had an M-CHAT follow-up interview by phone and then were assessed by a developmental paediatrician as indicated with a diagnosis of autism being made on clinical judgement. 13 (13.4%) of the 97 preterm infants screened positive on the M-CHAT compared to three (3.9%) of the 77 term infants (p = 0.036). On follow-up interview, three of the preterm infants remained positive (one was diagnosed with autism) compared to none of the te...Continue Reading

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Citations

Mar 5, 2016·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Emma J TelfordJames P Boardman
Jul 4, 2019·Journal of Autism and Developmental Disorders·Maëva BrayetteFrédérique Bonnet-Brilhault
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Sep 23, 2021·Journal of Neurodevelopmental Disorders·Catherine LavertyCaroline Richards

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