Screening for beta-thalassaemia trait in anaemic pregnant women

Gynecologic and Obstetric Investigation
Gabriela BencaiovaRoland Zimmermann

Abstract

To find a clinically practicable parameter for the identification of beta-thalassaemia trait (beta-TT) in anaemic pregnant women on the basis of routine use of haematological examination. During 1998-2002, 304 anaemic pregnant women were observed in anaemia consultation hours. A retrospective study was carried out with the aim of finding a screening method for beta-TT in anaemic pregnant women. We compared a sensitivity and a specificity of six different parameters for identification of beta-TT. On the basis of a sensitivity and a specificity for each parameter, we calculated Youden's index, the likelihood ratio and determined the receiver-operating curves. The logistic regression of the variables MCV, MCH and microcytosis was accomplished. The analysis using receiver-operating curves as well as a calculation of Youden's index showed that the best parameter for screening of beta-TT in anaemic pregnant women is MCV < or = 75 fl. For differentiation between patients with iron deficiency anaemia (IDA) alone and patients with beta-TT and concomitant IDA, microcytosis > or = 15% was the most sensitive. By using MCH we identified 100% of patients in the group with beta-TT but only 67% of patients in the group with IDA. Our results su...Continue Reading

References

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Citations

Mar 20, 2016·Journal of Medical Screening·Alireza MoafiHadi Moafi
Dec 20, 2008·American Journal of Clinical Pathology·Zhaohai YangVishnu V B Reddy

Related Concepts

Red Blood Cell Count Measurement
Mean Corpuscular Hemoglobin Concentration Determination
Hemoglobin A2
Hemoglobinopathies
Retrospective Studies
Receiver Operating Characteristic
Likelihood Functions
Thalassemia Minor
Iron Deficiency Anemia

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