Screening for beta-thalassaemia trait in anaemic pregnant women

Gynecologic and Obstetric Investigation
Gabriela BencaiovaRoland Zimmermann


To find a clinically practicable parameter for the identification of beta-thalassaemia trait (beta-TT) in anaemic pregnant women on the basis of routine use of haematological examination. During 1998-2002, 304 anaemic pregnant women were observed in anaemia consultation hours. A retrospective study was carried out with the aim of finding a screening method for beta-TT in anaemic pregnant women. We compared a sensitivity and a specificity of six different parameters for identification of beta-TT. On the basis of a sensitivity and a specificity for each parameter, we calculated Youden's index, the likelihood ratio and determined the receiver-operating curves. The logistic regression of the variables MCV, MCH and microcytosis was accomplished. The analysis using receiver-operating curves as well as a calculation of Youden's index showed that the best parameter for screening of beta-TT in anaemic pregnant women is MCV < or = 75 fl. For differentiation between patients with iron deficiency anaemia (IDA) alone and patients with beta-TT and concomitant IDA, microcytosis > or = 15% was the most sensitive. By using MCH we identified 100% of patients in the group with beta-TT but only 67% of patients in the group with IDA. Our results su...Continue Reading


Mar 1, 1993·Baillière's Clinical Haematology·A Cao, M C Rosatelli
Nov 1, 1995·Journal of Clinical Pathology·M RogersB Bain
Apr 17, 1998·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·C WanapirakA Tuggapichitti
Jul 23, 1998·British Journal of Haematology
Feb 9, 2002·American Journal of Hematology·D AslanC Altay
Nov 8, 2002·Pediatrics International : Official Journal of the Japan Pediatric Society·Aysin DemirAbdurrahman Kara
Jun 27, 2003·American Journal of Hematology·Wafaa LemsaddekLeonor Osório-Almeida


Mar 20, 2016·Journal of Medical Screening·Alireza MoafiHadi Moafi
Dec 20, 2008·American Journal of Clinical Pathology·Zhaohai YangVishnu V B Reddy

Related Concepts

Red Blood Cell Count Measurement
Mean Corpuscular Hemoglobin Concentration Determination
Hemoglobin A2
Retrospective Studies
Receiver Operating Characteristic
Likelihood Functions
Thalassemia Minor
Iron Deficiency Anemia

Related Feeds


Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Related Papers

European Journal of Obstetrics, Gynecology, and Reproductive Biology
A K al-MomenM Abbas
European Journal of Clinical Investigation
Alexander KrafftC Breymann
© 2021 Meta ULC. All rights reserved