Screening for CMV-specific T cell proliferation to identify patients at risk of developing late onset CMV disease

Bone Marrow Transplantation
H KrauseH Einsele

Abstract

Thirty patients undergoing allogeneic BMT were screened post-transplant together with their marrow donors for CMV-specific T cell proliferation and the occurrence of CMV disease. Twenty-one of these patients received a marrow transplant from an HLA-matched sibling donor, and nine from an HLA-matched unrelated donor. All these patients were either CMV seropositive and/or had received a transplant from a CMV-seropositive donor. Patients were monitored for CMV-viraemia until day +100 post-BMT by PCR and virus culture, and thereafter by virus culture only when clinically indicated. The proliferative T cell response was investigated at regular monthly intervals beginning on day +30. A proliferative response to HCMV (median, day +123) was documented in these patients between day +37 and +730 post-BMT. None of the patients with a documented CMV-specific T cell proliferation on day 120 (n = 17) developed CMV disease in the later post-transplant period, but of the patients lacking CMV-specific proliferation (n = 13), 30.8% developed CMV disease after day 120. Thus, patients lacking a CMV-specific T-helper cell response might benefit from sensitive screening for CMV infection and pre-emptive therapy after day +100.

Citations

Mar 6, 2008·International Journal of Hematology·Yuki Asano-MoriMineo Kurokawa
Jan 4, 2001·Human Immunology·M OnnoR Fauchet
Oct 15, 2003·Blood Reviews·Maher K GandhiAndrew J Carmichael
Sep 25, 2008·Bone Marrow Transplantation·P Ljungman
Jul 1, 2008·Bone Marrow Transplantation·P LjungmanUNKNOWN European Conference on Infections in Leukemia
Jan 4, 2008·The Journal of Infectious Diseases·Corinna La RosaDon J Diamond
Apr 21, 2012·Current Opinion in Hematology·Mark BoschJan Storek
Jan 13, 2009·Clinical Microbiology Reviews·Tania Crough, Rajiv Khanna
Oct 15, 2003·Clinical Microbiology Reviews·Ellen MeijerLeo F Verdonck
Mar 22, 2002·Journal of Virology·Martina SesterHans Köhler
Mar 21, 2009·Blood·Michael Boeckh, Per Ljungman
Oct 16, 2004·International Journal of Hematology·Hiroshi MatsubaraTatsutoshi Nakahata
Jun 29, 2001·Transplant Infectious Disease : an Official Journal of the Transplantation Society·J R Wingard
Jun 29, 2001·Transplant Infectious Disease : an Official Journal of the Transplantation Society·M Boeckh
Aug 2, 2014·Expert Review of Clinical Immunology·Dante Melendez, Raymund R Razonable
Jan 18, 2011·Hematology/oncology Clinics of North America·Per LjungmanMichael Boeckh
May 15, 2010·Infectious Disease Clinics of North America·Per LjungmanMichael Boeckh
Oct 27, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·François HaddadJose G Montoya
Sep 14, 2007·Blood Cells, Molecules & Diseases·Hermann EinseleGötz Ulrich Grigoleit
Apr 24, 2007·Best Practice & Research. Clinical Haematology·Michelle Geddes, Jan Storek
Apr 2, 2002·Best Practice & Research. Clinical Haematology·P Moss
Jul 16, 2015·Cellular and Molecular Life Sciences : CMLS·Miriam CiáurrizNatalia Ramírez
Jun 3, 2004·Human Immunology·Hermann Einsele, Holger Hebart
Jun 3, 2004·Human Immunology·Holger Hebart, Hermann Einsele
Jun 3, 2004·Human Immunology·Elio CastagnolaGiorgio Dini
Oct 6, 2007·Cytotherapy·M KappGu Grigoleit

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