Screening for cognitive dysfunction in Huntington's disease with the clock drawing test

International Journal of Geriatric Psychiatry
Paul W TerwindtErik van Duijn

Abstract

The aim of the study is to investigate the performance of the clock drawing test as a screening tool for cognitive impairment in Huntington's disease (HD) mutation carriers. The performance of the clock drawing test was assessed in 65 mutation carriers using the Shulman and the Freund scoring systems. The mini-mental state examination, the Symbol Digit Modalities Test, the Verbal Fluency Test, and the Stroop tests were used as comparisons for the evaluation of cognitive functioning. Correlations of the clock drawing test with various cognitive tests (convergent validity), neuropsychiatric characteristics (divergent validity) and clinical characteristics were analysed using the Spearman's rank correlation coefficient. Receiver-operator characteristic analyses were performed for the clock drawing test against both the mini-mental state examination and against a composite variable for executive cognitive functioning to assess optimal cut-off scores. Inter-rater reliability was high for both the Shulman and Freund scoring systems (ICC = 0.95 and ICC = 0.90 respectively). The clock drawing tests showed moderate to high correlations with the composite variable for executive cognitive functioning (mean ρ = 0.75) and weaker correlation...Continue Reading

References

Jan 1, 1979·Neurology·I Shoulson, S Fahn
Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Jun 1, 1992·Journal of the American Geriatrics Society·H TuokkoB L Beattie
Mar 1, 1986·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·N ButtersM Martone
Mar 1, 1996·Movement Disorders : Official Journal of the Movement Disorder Society
Jun 22, 2000·International Journal of Geriatric Psychiatry·K I Shulman
Apr 20, 2005·Journal of General Internal Medicine·Barbara FreundElias Shaheen
Jan 24, 2007·Lancet·Francis O Walker
Jul 6, 2007·Journal of Psychiatric Research·Evangelos VassosDimitrios Vassilopoulos
Dec 21, 2007·Arquivos de neuro-psiquiatria·Mauro R PiovezanLineu Cesar Werneck
Feb 5, 2008·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Emily J HubbardRobert A Stern
Feb 23, 2008·General Hospital Psychiatry·Elisabeth M KingmaRaymund A C Roos
Aug 20, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Laura MickesJody Corey-Bloom
Dec 22, 2010·Orphanet Journal of Rare Diseases·Raymund A C Roos
Jan 11, 2012·The Journal of Neuropsychiatry and Clinical Neurosciences·Peter J WagnerDavid B Arciniegas
Mar 28, 2012·The Journal of Neuropsychiatry and Clinical Neurosciences·Jennifer C ThompsonDavid Craufurd
Jan 2, 2013·Frontiers in Bioscience (Scholar Edition)·Eve M DumasRaymund A C Roos
Jun 15, 2013·International Journal of Geriatric Psychiatry·Brian J MainlandKenneth I Shulman
Jun 27, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Shea GluhmJody Corey-Bloom
Aug 22, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Jane S Paulsen, Jeffrey D Long
Sep 13, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Christopher A RossJason Brandt

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