Screening for Cognitive Function in Complete Immobility Using Brain-Machine Interfaces: A Proof of Principle Study

Frontiers in Neuroscience
Dorothée LuléAlbert C Ludolph

Abstract

Background: In many neurological conditions, there is a combination of decline in physical function and cognitive abilities. For far advanced stages of physical disability where speaking and hand motor abilities are severely impaired, there is a lack of standardized approach to screen for cognitive profile. Methods:N = 40 healthy subjects were included in the study. For proof of principle, N = 6 ALS patients were additionally measured. For cognitive screening, we used the Edinburgh cognitive and behavioral ALS screen (ECAS) in the standard paper-and-pencil version. Additionally, we adapted the ECAS to a brain-machine interface (BMI) control module to screen for cognition in severely advanced patients. Results: There was a high congruency between BMI version and the paper-and-pencil version of the ECAS. Sensitivity and specificity of the ECAS-BMI were mostly high whereas stress and weariness for the patient were low. Discussion/Conclusion: We hereby present evidence that adaptation of a standardized neuropsychological test for BMI control is feasible. BMI driven neuropsychological test provides congruent results compared to standardized tests with a good specificity and sensitivity but low patient load.

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Citations

Oct 17, 2020·Patient Related Outcome Measures·Tina TauleTiina Rekand

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Methods Mentioned

BETA
infrared spectroscopy

Software Mentioned

BCI2000
Emotiv Epoc

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