Screening for Down's syndrome: experience in an inner city health district

British Journal of Obstetrics and Gynaecology
E SaridoganA A Naftalin

Abstract

To review the experience of Down's syndrome screening in an inner city health district. In this retrospective study the names of the women were obtained from the Regional Cytogenetic Laboratory and District Down's Syndrome Register. Antenatal notes of the mothers were studied. Maternal age during the affected pregnancy, screening test performed if any, gestational age at booking and at screening, screening test results, and pregnancy outcome were reviewed. An inner city health district. Down's syndrome cases diagnosed prenatally and postnatally. None. Antenatal diagnosis of Down's syndrome was made in 15/45 women (33.3%); Edwards' syndrome was diagnosed antenatally in 2/5 women. Screening was not performed in eight women (17.8%) whose infants were affected by Down's Syndrome; it was also not performed in one woman whose baby was affected by Edwards' syndrome due to late presentation to the antenatal clinic or loss of the blood sample. Nineteen women (42.2%) with a Down's syndrome pregnancy and two women with a Edwards' syndrome pregnancy had had a negative screening test. Three women had had a positive screening test but declined amniocentesis. Among those who had a screening test, the overall detection rate of screening was 48...Continue Reading

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Citations

Sep 24, 1998·British Journal of Obstetrics and Gynaecology·C FordW E MacKenzie
Oct 30, 2004·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·R KeriakosM Zaklama
Jun 15, 2012·The Cochrane Database of Systematic Reviews·S Kate AlldredZarko Alfirevic
Mar 16, 2017·The Cochrane Database of Systematic Reviews·S Kate AlldredZarko Alfirevic
Dec 15, 2015·The Cochrane Database of Systematic Reviews·S Kate AlldredZarko Alfirevic
Dec 1, 2015·The Cochrane Database of Systematic Reviews·S Kate AlldredZarko Alfirevic
Jul 14, 2006·Prenatal Diagnosis·Nedra S WhiteheadSamuel F Posner
Mar 16, 2017·The Cochrane Database of Systematic Reviews·S Kate AlldredZarko Alfirevic

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