PMID: 3767266Mar 1, 1986Paper

Screening for early diabetic nephropathy

Annals of Clinical Biochemistry
S M Marshall, K G Alberti

Abstract

An albumin excretion rate of 30-150 micrograms/min is a strong predictor of future clinical diabetic nephropathy. The collection of urine samples commonly used is cumbersome and tedious for both patients and laboratory staff. We have therefore examined the usefulness of albumin:creatinine ratio measurement as a predictor of albumin excretion rates greater than 30 micrograms/min. Values above 3.5 for the albumin:creatinine ratio gave high sensitivity (98%) but low specificity (63%) while a value greater than 4.5 had a sensitivity of 96% and specificity of 72%. We conclude that the albumin:creatinine ratio in a first morning urine sample is useful as an initial screening test for microalbuminuria but that further analysis is required to select those with definite microalbuminuria.

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Citations

Jul 15, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·R J SpoonerB M Frier
Jan 1, 2013·Kidney International Supplements
Jul 26, 2011·Advances in Chronic Kidney Disease·Gautham Viswanathan, Ashish Upadhyay
Nov 6, 2008·Clinical Biochemistry·D WillemsC Gillet
Jun 5, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Christine A HoulihanGeorge Jerums
Apr 1, 2010·Nephrology·S ChadbanUNKNOWN CARI
Sep 1, 1988·Diabetic Medicine : a Journal of the British Diabetic Association·A S Hutchison, K R Paterson
Jan 1, 1994·Diabetic Medicine : a Journal of the British Diabetic Association·S J ConnellT L Dornan
Mar 1, 1992·Diabetic Medicine : a Journal of the British Diabetic Association·T F CundyJ Baker
Oct 1, 1991·Diabetic Medicine : a Journal of the British Diabetic Association·S M Marshall
Mar 1, 1990·Diabetic Medicine : a Journal of the British Diabetic Association·G F Watts, D Pillay
Mar 15, 1988·Clinica Chimica Acta; International Journal of Clinical Chemistry·G F WattsA Polak
Jan 1, 1990·Journal of Clinical Pathology·J C Townsend
Jun 1, 2001·Journal of the Royal Society of Medicine·L FoggensteinerJ Firth
Apr 25, 2009·Annals of Clinical Biochemistry·Edmund J LambPaul E Stevens
Oct 2, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Geeta G GyamlaniTimothy S Larson

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