Screening for hepatitis C in a general adult population in a low-prevalence area: the Tromsø study

BMC Infectious Diseases
H KilengE J Paulssen

Abstract

Chronic hepatitis C virus (HCV) infection can progress to cirrhosis and end-stage liver disease in a substantial proportion of patients. The infection is frequently asymptomatic, leaving many infected individuals unaware of the diagnosis until complications occur. This advocates the screening of healthy individuals. The aim of this study was to estimate the prevalence of HCV infection in the general adult population of the municipality of Tromsø, Norway, and to evaluate the efficiency of such an approach in a presumed low-prevalence area. The study was part of the seventh survey of the Tromsø Study (Tromsø 7) in 2015-2016. Sera from 20,946 individuals aged 40 years and older were analysed for antibodies to HCV (anti-HCV). A positive anti-HCV test was followed up with a new blood test for HCV RNA, and the result of any previous laboratory HCV data were recorded. Samples positive for anti-HCV and negative for HCV RNA were tested with a recombinant immunoblot assay. All HCV RNA positive individuals were offered clinical evaluation. Among 20,946 participants, HCV RNA was detected in 33 (0.2%; 95% CI: 0.1-0.3), of whom 13 (39.4%; 95% CI: 22.7-56.1) were unaware of their infection. The anti-HCV test was confirmed positive in 134 indi...Continue Reading

References

Aug 28, 2003·Scandinavian Journal of Gastroenterology·O DalgardH Bell
Jun 15, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anaïs Vallet-PichardStanislas Pol
Feb 7, 2009·European Journal of Public Health·Gaby SroczynskiUwe Siebert
Feb 12, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Leonard B Seeff
Nov 26, 2009·Drug and Alcohol Review·Jinhui ZhaoScott Macdonald
Feb 18, 2011·Epidemiology and Infection·C W HelsperG A de Wit
Mar 23, 2011·International Journal of Epidemiology·Bjarne K JacobsenInger Njølstad
Jan 4, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Maxine M DennistonRuth B Jiles
Feb 22, 2012·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Alain H LitwinWilliam N Southern
Aug 8, 2012·BMC Infectious Diseases·Peer Brehm ChristensenSusan Cowan
Aug 10, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Philip R SpradlingUNKNOWN Chronic Hepatitis Cohort Study Investigators
Oct 5, 2012·BMJ : British Medical Journal·Christopher J A DuncanRay Fox
Apr 10, 2014·Journal of Viral Hepatitis·H WedemeyerE Gower
May 21, 2014·PloS One·Benjamin P LinasBruce R Schackman
Jan 7, 2015·Journal of Viral Hepatitis·E GaneC Estes
Sep 7, 2016·Scandinavian Journal of Gastroenterology·Katharina BüschJonas Söderholm
Feb 7, 2017·Journal of Medical Virology·Geane Lopes FloresLivia Melo Villar
Feb 9, 2017·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Anne C MoormanSaleem Kamili
Apr 14, 2017·The Lancet. Gastroenterology & Hepatology·UNKNOWN Polaris Observatory HCV Collaborators
Aug 5, 2017·BMC Infectious Diseases·Hinta MeijerinkHilde Kløvstad
Aug 9, 2017·Current Epidemiology Reports·Alexander J MillmanClaudia Vellozzi
Jun 26, 2018·European Journal of Gastroenterology & Hepatology·Laura Gómez-Escolar ViejoJaime Valverde de la Osa
Sep 20, 2018·Journal of Hepatology·Sylvie Deuffic-BurbanYazdan Yazdanpanah
Nov 1, 2018·Hepatology International·Steve JohnsonMichael Schultz

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Citations

Jan 31, 2020·Journal of Viral Hepatitis·Rosaida Md SaidMuhammad Radzi Abu Hassan
Jul 12, 2020·Scientific Reports·Masayuki TatemichiMasaaki Korenaga
Dec 31, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·C Nelson HayesKazuaki Chayama

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