Screening for histone codebreakers

The Journal of Biological Chemistry
Mark T Bedford

Abstract

The lysine methyltransferase NSD2 is overexpressed and carries gain-of-function mutations in a number of different cancers, making it an attractive therapeutic target. However, no specific small molecule inhibitors have been identified for this enzyme, responsible for depositing the H3K36me2 mark on histones. A new study reports a robust platform for high-throughput screening (HTS) assays to facilitate this discovery.

References

Jan 19, 2000·Nature·B D Strahl, C D Allis
Oct 8, 2009·The Journal of Biological Chemistry·Yan LiDanny Reinberg
Mar 10, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Heidi Rye HudlebuschKristian Helin

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.

Related Papers

BMJ : British Medical Journal
A Hodges
Air Medical Journal
John R Clark
© 2022 Meta ULC. All rights reserved