Screening for inborn errors of metabolism in high-risk children: a 3-year pilot study in Zhejiang Province, China.

BMC Pediatrics
Xinwen HuangZhengyan Zhao

Abstract

Tandem mass spectrometry (MS/MS) has been available in China for 8 years. This technique makes it possible to screen for a wide range of previously unscreened inborn errors of metabolism (IEM) using a single test. This 3-year pilot study investigated the screening, diagnosis, treatment and outcomes of IEM in symptomatic infants and children. All children encountered in the Newborn Screening Center of Zhejiang Province during a 3-year period with symptoms suspicious for IEM were screened for metabolic diseases. Dried blood spots were collected and analyzed by tandem mass spectrometry. The diagnoses were further confirmed by clinical symptoms and biochemical analysis. Neonatal intrahepatic cholestasis caused by citrin deficiency, ornithine transcarbamylase deficiency and primary carnitine deficiency were confirmed by DNA analysis. A total of 11,060 symptomatic patients (6,720 boys, 4,340 girls) with a median age of 28.8 months (range: 0.04-168.2 months) were screened. Among these, 62 were diagnosed with IEM, with a detection rate of 0.56%. Thirty-five were males and 27 females and the median age was 3.55 months (range 0.07-143.9 months). Of the 62 patients, 27 (43.5%) had aminoacidemias, 26 (41.9%) had organic acidemias and nine ...Continue Reading

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Citations

Nov 30, 2013·Journal of Nutrition and Metabolism·Muhammad Rafique
Apr 2, 2016·Molecular Genetics and Metabolism·RaeLynn ForsythUNKNOWN Inborn Errors of Metabolism Collaborative
Apr 19, 2020·Journal of Pediatric Endocrinology & Metabolism : JPEM·Nan YangYuan-Yuan Kong
Apr 25, 2013·Journal of Pediatric Endocrinology & Metabolism : JPEM·Meng Meng, Yu-Ping Zhang
May 4, 2017·World Journal of Pediatrics : WJP·Qing KeMichele Gatheridge
Oct 16, 2020·Clinica Chimica Acta; International Journal of Clinical Chemistry·Xinmei MaoJia Liu

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