Screening for malignancy in primary sclerosing cholangitis (PSC)

Current Gastroenterology Reports
Saira A Khaderi, Norman L Sussman

Abstract

Primary sclerosing cholangitis (PSC) is a frequently progressive and fatal disease. Death from cancer occurs in a significant subset of patients with PSC. Patients with PSC have a 10 to 15 % lifetime risk of developing cholangiocarcinoma (CCA). About one third of CCAs are present in the first year after a diagnosis of PSC; the remainder are present with a frequency of about 1.5 % each year. Patients with concomitant PSC and inflammatory bowel disease (IBD) have a 4-fold higher risk of colorectal cancer (CRC) than patients with IBD alone and a 10-fold higher risk of CRC than the general population. The risk does not diminish with liver transplantation. This patient population also has a high frequency of carcinoma in gallbladder mass lesions. The risk for hepatocellular carcinoma (HCC) in the presence of cirrhosis is uncertain-two large cohort studies suggest that HCC is not as common as in other causes of cirrhosis. Although AASLD guidelines do not recommend routine screening for liver tumors in patients with PSC, we recommend MRI/MRCP and serum CA 19-9 levels in patients with PSC every 6 months to screen for CCA, HCC, pancreatic cancer, and gallbladder cancer. Screening colonoscopy at the diagnosis of PSC and surveillance colo...Continue Reading

References

Jan 11, 1991·Annals of Surgery·C B RosenN F LaRusso
Apr 6, 1995·The New England Journal of Medicine·Y M Lee, M M Kaplan
Oct 1, 1994·Mayo Clinic Proceedings·R H Wiesner
Feb 28, 2002·Journal of Hepatology·Annika BergquistUlrika Broomé
Apr 2, 2004·The American Journal of Gastroenterology·Kelly BurakKeith D Lindor
Aug 28, 2004·The American Journal of Gastroenterology·Benjamin R KippLewis R Roberts
Sep 1, 2005·Digestive Diseases and Sciences·Cynthia LevyKeith D Lindor
Jan 29, 2008·Journal of Hepatology·Karouk SaidAnnika Bergquist
Jun 9, 2009·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver
Oct 31, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sanjay Y BangarulingamKeith D Lindor
Jan 27, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Roger ChapmanUNKNOWN American Association for the Study of Liver Diseases
Apr 28, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J Sint NicolaasS J O Veldhuyzen-van Zanten
Feb 22, 2011·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Emmanouil SinakosKeith D Lindor
Mar 23, 2011·Inflammatory Bowel Diseases·Ibrahim A HanounehBret A Lashner
Jul 13, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Johan FeveryWerner Van Steenbergen
Jul 28, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Nataliya RazumilavaKeith D Lindor
Oct 28, 2011·The American Journal of Gastroenterology·John E EatonKeith D Lindor
Jan 17, 2012·Journal of Hepatology·Kirsten BoonstraCyriel Y Ponsioen
May 15, 2012·Scandinavian Journal of Gastroenterology·Kristin Kaasen JørgensenKirsten Muri Boberg
Jun 2, 2012·European Journal of Gastroenterology & Hepatology·Michael H ChapmanStephen P Pereira
Jun 19, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kirsten BoonstraUNKNOWN EpiPSCPBC Study Group
Sep 11, 2013·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Siddharth SinghJayant A Talwalkar
Feb 18, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Roman ZenouziChristoph Schramm

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Citations

Jul 2, 2016·The Journal of Surgical Research·Xiaolei LiuYongliang Sun
Sep 23, 2016·The New England Journal of Medicine·Konstantinos N Lazaridis, Nicholas F LaRusso
Dec 29, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Jennifer L Horsley-SilvaKeith D Lindor
Apr 7, 2016·Journal of Pediatric Gastroenterology and Nutrition·Scott B RaymondKatherine Nimkin
Jan 16, 2016·Pediatric Gastroenterology, Hepatology & Nutrition·Jisun YoonKyung Mo Kim
Apr 7, 2020·The American Journal of Gastroenterology·Ayesha ShahGerald Holtmann
Feb 23, 2019·World Journal of Gastrointestinal Endoscopy·Neil Bharat Marya, James H Tabibian
Feb 21, 2019·World Journal of Gastroenterology : WJG·Brian M FungJames H Tabibian
Aug 3, 2019·Japanese Journal of Radiology·Mami HamaokaSatoshi Kobayashi
Jun 12, 2020·Therapeutic Advances in Gastroenterology·Jordan E Axelrad, Shailja C Shah
Sep 8, 2020·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·UNKNOWN Cholangiocarcinoma Working Group

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