Screening for membrane hormone receptor expression in primary aldosteronism

European Journal of Endocrinology
O ZwermannM Reincke

Abstract

The investigation of expression and functional relevance of G-protein coupled receptors in primary aldosteronism (PA) by molecular and clinical studies. Tissues of 14 aldosterone-producing adenomas (APA), of one unilateral adrenal hyperplasia and of six healthy adult adrenal glands; 12 patients with confirmed PA due to APA; (n=5), idiopathic hyperaldosteronism (n=7) and 8 control subjects (C). The tissues were subjected to a quantitative PCR for determination of mRNA expression levels of AT2R1, GIPR, MC2R, GnRHR, LHR, TRHR, TSHR, glucagon-R, V1aR, V2R, and 5-HT4R. The patients and controls were enrolled in a test protocol consisting of stimulation by posture, mixed meal, ACTH, GnRH, TRH, glucagon, vasopressin, and metoclopramide (MCP). Three patients could be analyzed by both studies. A positive response was defined as an aldosterone increase of more than 50% following stimulation. All the tissues revealed AT2R1, MC2R, AVPR, and 5-HT4R mRNA expression. LHR mRNA was found in normal adrenals and 13 adrenal tumors. By contrast with normal adrenals tumorous adrenal tissue expressed GnRHR mRNA (4/15) and TSHR mRNA (1/15). Both the patients and controls responded to posture, ACTH, glucagon, AVP, and MCP. Specific responses were seen ...Continue Reading

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Citations

Sep 23, 2014·Molecular and Cellular Endocrinology·Silvia MonticoneWilliam E Rainey
Oct 3, 2014·Pathology International·Yasuhiro NakamuraHironobu Sasano
May 15, 2015·European Journal of Endocrinology·Nada El GhorayebAndré Lacroix
Nov 30, 2014·Molecular and Cellular Endocrinology·H LefebvreE Louiset
Dec 17, 2014·Molecular and Cellular Endocrinology·Celso E Gomez-SanchezElise P Gomez-Sanchez
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Dec 30, 2014·European Journal of Endocrinology·George PiaditisGregory Kaltsas
May 10, 2016·Annales d'endocrinologie·Ester Landau, Laurence Amar
Jul 26, 2016·Frontiers in Endocrinology·Nada El GhorayebAndré Lacroix
Feb 27, 2016·The Journal of Clinical Endocrinology and Metabolism·Nada El GhorayebAndré Lacroix
Aug 29, 2014·Endocrinology·Brasilina CarocciaGian Paolo Rossi
May 5, 2018·The Journal of Clinical Endocrinology and Metabolism·Nadia GagnonIsabelle Bourdeau
Aug 14, 2019·The Journal of Clinical Endocrinology and Metabolism·Taweesak WannachaleeAdina F Turcu
Nov 19, 2019·The Journal of Clinical Investigation·Matthew J TaylorWilliam E Rainey
Oct 2, 2020·The Journal of Clinical Endocrinology and Metabolism·Matthieu St-JeanAndré Lacroix
Apr 3, 2021·Frontiers in Endocrinology·Jung Soo LimAdina F Turcu
Jun 13, 2021·The Journal of Clinical Endocrinology and Metabolism·Yuta TezukaAdina F Turcu
Apr 27, 2010·Current Opinion in Endocrinology, Diabetes, and Obesity

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