Screening for Opioid and Stimulant Exposure In Utero Through Targeted and Untargeted Metabolomics Analysis of Umbilical Cords.

Therapeutic Drug Monitoring
Srivalli Swathi MamillapalliSrikanth Ravisankar

Abstract

Neonatal abstinence syndrome is an array of signs and symptoms experienced by a newborn due to abrupt discontinuation of intrauterine exposure to certain drugs, primarily opioids. In the United States, the incidence of neonatal abstinence syndrome has tripled over the past decade. The current standard of care for drug testing includes the analysis of infant urine and meconium. Sample collection is associated with several limitations, including diaper media interferences, limited sample amount, sample heterogeneity, and the need for professional staff for collection. Umbilical cord tissue has emerged as a convenient sample matrix for testing owing to its universal availability. The purpose of this study was to examine umbilical cords using an untargeted metabolomics approach to determine the detected drugs and validate an analytical method to confirm and quantify the identified drugs. A metabolomics analysis was performed with 21 umbilical cords to screen for drugs and drug metabolites by liquid chromatography-mass spectrometry. Drugs were identified using the National Institute of Standards and Technology database, and an analytical method was developed and validated using secondary liquid chromatography-mass spectrometry instr...Continue Reading

References

Aug 13, 1998·Journal of Chromatography. B, Biomedical Sciences and Applications·C MooreD Lewis
Mar 21, 2007·Analytical and Bioanalytical Chemistry·Teresa Gray, Marilyn Huestis
Nov 29, 2007·Therapeutic Drug Monitoring·Jaime LozanoSimona Pichini
Dec 31, 2010·Therapeutic Drug Monitoring·Stephanie J MarinGwendolyn A McMillin
Jul 26, 2011·International Journal of Pediatrics·Karen J FarstR Whit Hall
Feb 1, 2012·Pediatrics·Mark L HudakUNKNOWN American Academy of Pediatrics
May 2, 2012·JAMA : the Journal of the American Medical Association·Stephen W PatrickMatthew M Davis
Jul 16, 2013·Therapeutic Drug Monitoring·Marta ConcheiroManuel López-Rivadulla
Jul 30, 2014·Pediatrics·Prabhakar Kocherlakota
May 1, 2015·Journal of Perinatology : Official Journal of the California Perinatal Association·S W PatrickW O Cooper
Aug 12, 2016·MMWR. Morbidity and Mortality Weekly Report·Jean Y KoWanda D Barfield
Sep 7, 2016·Drug Testing and Analysis·Marta ConcheiroManuel López-Rivadulla
Oct 1, 2016·Biological Trace Element Research·Chunmei LiangFangbiao Tao
Jan 10, 2018·Internal Medicine Journal·Ju Lee Oei
Feb 9, 2018·Therapeutic Drug Monitoring·Simuli L WabuyeleGwendolyn A McMillin
Mar 22, 2018·Bioanalysis·Marta Concheiro, Marilyn A Huestis
Mar 25, 2018·Pediatrics·Tyler N A WinkelmanStephen W Patrick
Aug 20, 2019·Therapeutic Drug Monitoring·Annagiulia Di TranaJeremy Carlier

❮ Previous
Next ❯

Citations

Aug 10, 2021·Preparative Biochemistry & Biotechnology·Xiaoyue ShanBingsheng Yang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.