PMID: 2106960Feb 3, 1990Paper

Screening for prolonged incubation of HTLV-I infection in British and Jamaican relatives of British patients with tropical spastic paraparesis

BMJ : British Medical Journal
J K CruickshankA Dalgleish

Abstract

To compare the prevalence of antibody to and proviral DNA of the retrovirus HTLV-I in relatives of 11 British patients with tropical spastic paraparesis who had migrated from Jamaica before they developed symptoms, and to examine factors possibly related to transmission of HTLV-I. Migrant, family study. Antibody state was determined by several methods and confirmed by western blotting; the polymerase chain reaction was used to detect proviral DNA. Britain and Jamaica. All available first degree relatives: those born and still resident in Jamaica (group 1); those born in Jamaica who migrated to Britain (group 2); and index patients' children who were born and resident in Britain (group 3). All had been breast fed and none had had blood transfusions. Of the 66 living relatives, 60 were traced. Seroprevalence among those born in Jamaica (irrespective of current residence) was 22% (10/46; 95% confidence limits 9 to 34%) compared with zero among British born offspring (0/14) and was higher in group 2 at 33% (7/21; 12 to 55%) than in group 1 at 12% (3/25; 0 to 25%). (Patients in group 1 had the greatest mean age.) Proviral DNA was not detected in any subject negative for HTLV-I antibody, making prolonged viral incubation in those neg...Continue Reading

References

Jun 15, 1989·International Journal of Cancer. Journal International Du Cancer·T KondoT Funatsu
Aug 1, 1989·Brain : a Journal of Neurology·J K CruickshankD H Miller
Oct 1, 1989·Annals of Internal Medicine·E L MurphyW A Blattner
Nov 1, 1986·The Journal of Infectious Diseases·W KajiyamaK Okochi
Dec 15, 1986·International Journal of Cancer. Journal International Du Cancer·G J MillerM F Greaves
Dec 15, 1987·International Journal of Cancer. Journal International Du Cancer·K KusuharaK Ueda
Jan 1, 1988·Annals of Neurology·P Rodgers-JohnsonD C Gajdusek
Feb 15, 1989·International Journal of Cancer. Journal International Du Cancer·E L MurphyW A Blattner
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·W A BlattnerM Robert-Guroff
Dec 1, 1988·AIDS Research and Human Retroviruses·A DalgleishD Catovsky
Jun 1, 1987·American Journal of Medical Genetics·L MadisenM E Hodes
Dec 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·D D HoM S Hirsch
Dec 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·J A HoxieD B Cines
Mar 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·M YoshidaY Hinuma
Sep 1, 1964·Brain : a Journal of Neurology·R D MONTGOMERYW H MCMENEMEY

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Citations

Jul 1, 1991·European Journal of Epidemiology·S Tokudome
Mar 1, 1993·Transactions of the Royal Society of Tropical Medicine and Hygiene·R D Montgomery
Sep 25, 1998·Journal of Dermatological Science·L GengT Kanzaki
Apr 1, 1993·Epidemiology and Infection·S NightingaleU Desselberger
Sep 1, 1993·AIDS Research and Human Retroviruses·N MonplaisirL Gazzolo
Apr 8, 2010·The Journal of the Acoustical Society of America·Paul D Teal, Mark A Poletti
Mar 10, 1990·BMJ : British Medical Journal·S Nightingale, U Desselberger
Jul 14, 1990·BMJ : British Medical Journal·J Weber
Nov 13, 1993·BMJ : British Medical Journal·A G Dalgleish
Aug 1, 1991·Journal of Neurology, Neurosurgery, and Psychiatry·P RudgeJ K Cruickshank
Jun 21, 2005·Virology·Marie-Eve ParéBenoit Barbeau
Dec 1, 1990·Arquivos de neuro-psiquiatria·A Spina-FrançaL A Bacheschi
Jan 1, 1996·The Journal of Infection·S HoqueJ Breuer
Sep 1, 1990·BMJ : British Medical Journal
Sep 1, 1990·BMJ : British Medical Journal·J Gibbs
Sep 1, 1990·BMJ : British Medical Journal·M GreavesD R Triger
Sep 1, 1990·BMJ : British Medical Journal
Mar 1, 1995·British Journal of Haematology·E MatutesD Catovsky

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