Screening for pulmonary arterial hypertension in an unselected prospective systemic sclerosis cohort

The European Respiratory Journal
Els VandecasteeleVanessa Smith

Abstract

Screening for pulmonary arterial hypertension (PAH) in systemic sclerosis (SSc) improves outcomes. The DETECT screening algorithm is recommended in a high-risk SSc subgroup. This study aims to compare prospectively the positive predictive value of screening using the DETECT algorithm and the 2009 European Society of Cardiology/European Respiratory Society (ESC/ERS) guidelines, and to compare their cost-effectiveness in an unselected, day-to-day SSc population. Post hoc, screening according to the 2015 ESC/ERS guidelines using echocardiographic parameters alone ("2015 echo screening") or combined with the DETECT algorithm ("2015 combined screening") in high-risk subjects was analysed.195 consecutive SSc patients included in the Ghent University Hospital SSc cohort were screened using different algorithms.The referral rate for right heart catheterisation was 32% (63 out of 195 patients) (46/4/13/34/40 patients using the DETECT algorithm/2009 guidelines/both/2015 echo screening/2015 combined screening). Right heart catheterisation was performed in 53 patients (84%) (36 (78%)/four (100%)/13 (100%)/28 (82%)/32 (80%) patients recommended by the DETECT algorithm/2009 guidelines/both/2015 echo screening/2015 combined screening). PAH wa...Continue Reading

References

Feb 1, 1988·Postgraduate Medical Journal·A J BarnettG O Littlejohn
Mar 3, 2007·Annals of the Rheumatic Diseases·Virginia D Steen, Thomas A Medsger
Mar 29, 2008·American Journal of Respiratory and Critical Care Medicine·Nicole S L GohAthol U Wells
May 12, 2009·Chest·Eric HachullaUNKNOWN French PAH-SSc Network
May 21, 2013·Annals of the Rheumatic Diseases·J Gerry CoghlanUNKNOWN DETECT study group
Sep 12, 2013·Arthritis and Rheumatism·Dinesh KhannaUNKNOWN Scleroderma Foundation and Pulmonary Hypertension Association
Mar 5, 2014·Arthritis & Rheumatology·Svetlana I NihtyanovaChristopher P Denton
Dec 11, 2014·Arthritis Research & Therapy·Scott H VisovattiDinesh Khanna
Apr 15, 2016·Acta Clinica Belgica·Els H VandecasteeleV Smith

❮ Previous
Next ❯

Citations

Mar 1, 2018·Current Rheumatology Reports·Sneha M Sundaram, Lorinda Chung
Apr 6, 2018·The European Respiratory Journal·Robin Condliffe, Gabor Kovacs
May 13, 2017·The European Respiratory Journal·Nermin Diab, Paul M Hassoun
Nov 13, 2019·Clinical Chemistry and Laboratory Medicine : CCLM·Lisa FlorinCarolien Bonroy
Aug 18, 2017·Current Opinion in Rheumatology·Christopher J Mullin, Stephen C Mathai
Jun 23, 2019·Annals of the Rheumatic Diseases·Mike BeckerUNKNOWN EUSTAR Collaborators (numerical order of centres)
Nov 8, 2018·RMD Open·Vanessa SmithMarco Matucci-Cerinic
Aug 2, 2019·European Respiratory Review : an Official Journal of the European Respiratory Society·Jason WeatheraldMarc Humbert
Oct 29, 2018·Clinical Rheumatology·Patricia CorzoEva Balcells
Sep 3, 2019·The Journal of Rheumatology·Vanessa SmithMaurizio Cutolo
May 26, 2020·Journal of Endocrinological Investigation·S PaolinoM Cutolo
Oct 6, 2019·Rheumatology·Greta PaciniMaurizio Cutolo
Nov 20, 2020·The International Journal of Cardiovascular Imaging·Andres Mora CarpioSunil Sharma
Jun 17, 2020·European Journal of Internal Medicine·Cosimo BruniMarco Matucci-Cerinic
Jun 3, 2021·Diagnostics·Mario Naranjo, Paul M Hassoun
Jul 27, 2021·Orphanet Journal of Rare Diseases·Eric HachullaUNKNOWN Collaborators
Aug 24, 2021·European Journal of Clinical Investigation·Amber VanhaeckeUNKNOWN EULAR Study Group on Microcirculation in Rheumatic Diseases

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.