Screening for pulmonary arterial hypertension in systemic sclerosis: A systematic literature review.

European Journal of Internal Medicine
C BruniMarco Matucci-Cerinic

Abstract

Pulmonary arterial hypertension (PAH) carries a high morbidity and mortality burden in Systemic Sclerosis (SSc). Therefore, PAH screening and early detection are pivotal. A systematic literature review (SLR) to search for all screening tools and modalities for SSc-PAH was performed in reference to right heart catheterization as diagnostic gold standard. Papers from 2 previously published SLRs and derived from a systematic search on Pubmed, EMBASE, Web of Science for papers published from 03/10/2017 to 31/12/2018 were manually included. A total of 199 papers were reviewed and 32 were extracted, with a low bias risk according to QUADAS2. Echocardiography, pulmonary function tests, clinical features and serum biomarkers were the most frequently tools used for screening, with different parameters combined in a variable fashion, as single item or as part of composite algorithms. Among the composite algorithms, the DETECT score, ESC/ERS 2009 or 2015 guidelines, ASIG and ITINER-air algorithms were the most commonly used in a wide range of patients. In different cohorts, DETECT and ASIG showed higher sensitivity and negative predictive value than ESC/ERS 2009. In conclusion, the literature shows echocardiography as the leading screenin...Continue Reading

References

May 12, 2009·Chest·Eric HachullaUNKNOWN French PAH-SSc Network
Oct 19, 2011·Annals of Internal Medicine·Penny F WhitingUNKNOWN QUADAS-2 Group
Nov 23, 2011·Clinical Rheumatology·Pavel JansaAles Linhart
Nov 28, 2012·Annals of the Rheumatic Diseases·David LaunayMarc Humbert
May 21, 2013·Annals of the Rheumatic Diseases·J Gerry CoghlanUNKNOWN DETECT study group
Aug 30, 2013·The New England Journal of Medicine·Tomás PulidoUNKNOWN SERAPHIN Investigators
Mar 5, 2014·Arthritis & Rheumatology·Svetlana I NihtyanovaChristopher P Denton
Sep 30, 2016·BMC Pulmonary Medicine·Kathleen MorrisroeUNKNOWN Australian Scleroderma Interest Group (ASIG)
Mar 9, 2017·Arthritis Research & Therapy·Kathleen MorrisroeUNKNOWN Australian Scleroderma Interest Group (ASIG)
May 13, 2017·The European Respiratory Journal·Els VandecasteeleVanessa Smith
Jun 4, 2017·Arthritis Research & Therapy·Kathleen MorrisroeUNKNOWN Australian Scleroderma Interest Group (ASIG)
Aug 19, 2017·The European Respiratory Journal·Sean GaineMarius M Hoeper
Dec 30, 2017·European Journal of Clinical Investigation·Masaru Kato, Tatsuya Atsumi
Apr 25, 2018·Arthritis & Rheumatology·Anna-Maria Hoffmann-VoldØyvind Molberg
Jul 28, 2018·The European Respiratory Journal·Thibaud SoumagneBruno Degano
Dec 14, 2018·The European Respiratory Journal·Gérald SimonneauRogerio Souza

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Citations

Jan 12, 2021·Frontiers in Medicine·Barbara RuaroCosimo Bruni
Feb 9, 2021·European Journal of Internal Medicine·Cosimo BruniMarco Matucci-Cerinic
Mar 7, 2021·Pharmaceuticals·Barbara RuaroCosimo Bruni
Mar 20, 2021·Best Practice & Research. Clinical Rheumatology·Cosimo Bruni, Laura Ross

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