Screening for symptomatic metal sensitivity: a prospective study of 92 patients undergoing total knee arthroplasty

Biomaterials
Yasuo NikiYoshiaki Toyama

Abstract

Metal sensitivity (MS) reactions to implant metals represent a rare but well-documented complication following total joint arthroplasty (TJA). Although 20-25% of post-TJA patients develop MS, only a few highly susceptible patients (< 1%) exhibit symptoms. Whether surgeons should perform screening for MS is currently a matter of debate. The present study investigated the clinical importance of screening for patients predisposed to symptomatic MS, and the specific metals causing symptomatic MS following total knee arthroplasty (TKA). Between 2000 and 2002, a total of 108 primary TKAs were performed on 92 patients. Preoperatively, all patients underwent modified lymphocyte stimulation test (mLST) to Ni, Co, Cr, and Fe. Of the 92 patients, 24 (26%) displayed positive preoperative responses to at least one metal. Five patients displayed implant metal-related eczema and were all mLST-positive preoperatively, suggesting that screening for symptomatic MS is clinically useful. Two of these underwent revision TKA and thereafter, eczema healed and mLST results changed from positive to negative. All mLST-positive patients were divided into three groups: Group I, patients with eczema; Group II, patients with clear history of MS; and Group I...Continue Reading

References

Oct 1, 1992·Contact Dermatitis·C MerleR Laurent
Jan 1, 1992·Contact Dermatitis·S BuchetP Agache
Apr 1, 1980·American Journal of Surgery·M B MayorS A Brown
Feb 1, 1980·Acta Orthopaedica Scandinavica·A S CarlssonH Möller
Oct 1, 1980·Annals of the Rheumatic Diseases·K ChristiansenP J Zilko
Feb 1, 1994·Contact Dermatitis·D GuimaraensL Condé-Salazar
May 1, 1993·Contact Dermatitis·D J Gawkrodger
Mar 1, 1997·Biochimica Et Biophysica Acta·S D Goldstone, N H Hunt
Jul 11, 1998·Journal of Biomedical Materials Research·S M HorowitzC K Ritchie

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Citations

Aug 13, 2011·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Romain Seil, Dietrich Pape
Apr 11, 2012·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Emmanuel Thienpont, Yorick Berger
Oct 21, 2006·Respirology : Official Journal of the Asian Pacific Society of Respirology·Keiko HisatomiShigeru Kohno
Sep 4, 2010·American Journal of Clinical Dermatology·Amy V Prakash, Mark D P Davis
Oct 9, 2014·The Journal of Clinical Investigation·Shadmehr DemehriWayne M Yokoyama
Aug 1, 2012·Materials Science & Engineering. C, Materials for Biological Applications·L ReclaruH Lüthy
Jul 29, 2010·The Journal of Arthroplasty·Xiang GaoLi-dong Wu
Dec 25, 2007·Biomaterials·Donatella GranchiArmando Giunti
Feb 1, 2007·Journal of Biomedical Materials Research. Part a·Yasuo NikiYoshiaki Toyama
Oct 1, 2011·Contact Dermatitis·Philippa J Cousen, David J Gawkrodger
Nov 7, 2015·Case Reports in Orthopedics·Farhan SyedMohammad Faisal
Apr 3, 2016·The Bone & Joint Journal·S Middleton, A Toms
Mar 10, 2015·The American Journal of Medicine·Alexander L FogelKavita Y Sarin
May 13, 2015·The Journal of Allergy and Clinical Immunology. in Practice·Luz FonacierDana Wallace
Jan 13, 2015·Dermatitis : Contact, Atopic, Occupational, Drug·Megan M Wood, Erin M Warshaw
Apr 27, 2016·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·M ThomsenP Thomas
May 23, 2016·BMC Musculoskeletal Disorders·Masahiro HasegawaAkihiro Sudo
May 25, 2016·Orthopedics·Franziska BeyerJörg Lützner
Jan 9, 2016·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Kazuaki SonofuchiEiji Itoi
Apr 28, 2007·Acta Orthopaedica·Wolf-Christoph WitzlebKlaus-Peter Guenther
Apr 10, 2013·The Journal of International Medical Research·Yirong Zeng, Wenjun Feng
Apr 5, 2018·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Anne PostlerJörg Lützner
Jan 18, 2011·The Journal of Rheumatology·Khalid AlzahraniNizar Mahomed
Jan 21, 2018·BMJ Case Reports·Fidel PeatAlastair Vince
Dec 6, 2012·International Journal of Occupational Medicine and Environmental Health·Beata KręciszDorota Chomiczewska-Skóra
Jun 26, 2012·International Journal of Occupational Medicine and Environmental Health·Beata KręciszJan Stetkiewicz
Nov 10, 2015·Dermatitis : Contact, Atopic, Occupational, Drug·Kerry HeitmillerAnthony A Gaspari
Dec 21, 2016·Dermatology and Therapy·Wendy Z W Teo, Peter C Schalock
Feb 9, 2017·HSS Journal : the Musculoskeletal Journal of Hospital for Special Surgery·Martin FaschingbauerFriedrich Boettner
Jun 19, 2019·Journal of Orthopaedic Surgery and Research·Robert L ZondervanCharles J Taunt
Nov 25, 2016·BMC Musculoskeletal Disorders·Anna Maria CarossinoMaria Luisa Brandi
Jan 11, 2017·Archives of Orthopaedic and Trauma Surgery·Ioannis P StathopoulosIoannis Tsarouchas
Aug 16, 2018·Journal of Experimental Orthopaedics·David R LionbergerAndreana Rivera
Oct 24, 2018·MMW Fortschritte der Medizin·Florian PohligRüdiger von Eisenhart-Rothe
Dec 2, 2014·JBJS Reviews·Jad Bou MonsefMark Gonzalez
Jan 30, 2020·Endocrine, Metabolic & Immune Disorders Drug Targets·Marta TramontanaLuca Stingeni

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