Screening for the anti-inflammation quality markers of Xiaojin Pills based on HPLC-MS/MS method, COX-2 inhibition test and protein interaction network

Scientific Reports
Xi XiongDing-Kun Zhang

Abstract

Nowadays, breast disorders seriously affect women's health in an increasing number. In China, Xiaojin Pills are commonly used in the treatment of breast diseases. Doctors have concluded that the combined use of Xiaojin Pills with conventional therapy can significantly improve the efficacy with fewer side effects. However, the prescription of Xiaojin Pills is complicated and their quality control methods cannot completely ensure the quality of Xiaojin Pills. On the basis of its mechanism, our study combined chemical evaluation and biological evaluation to identify the anti-inflammatory markers of Xiaojin Pills. In this manuscript, 13 compounds in Xiaojin Pills were quantified. At the same time, the cyclooxygenase-2 inhibition rates of different Xiaojin Pills were measured and the possible markers were screened by spectrum-effect relationship. Further, anti-inflammatory activities of markers were verified and protein interaction network was analyzed, identifying the components of Protocatechuate, Beta-Boswellic acid and Levistilide A as the anti-inflammatory quality markers of Xiaojin Pills. We hope our studies can provide a scientific theoretical basis for accurately quality control of Xiaojin Pills and reasonable suggestions fo...Continue Reading

References

Feb 13, 2001·The Journal of Clinical Investigation·J L StockL P Audoly
Jun 26, 2009·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Wei-Jun KongZu-Lun Li
Feb 23, 2013·Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan·Guijuan ZhangYinghui Zheng
Apr 2, 2015·Environmental Toxicology and Pharmacology·Tao ChenChuhao Yang
Oct 21, 2016·Clinical Obstetrics and Gynecology·Brian Orr, Joseph L Kelley
Jan 6, 2017·International Journal of Chronic Obstructive Pulmonary Disease·Guohua YuHongjun Yang
Jan 6, 2017·Scientific Reports·Jun TianJean Jacques Lebrun
Jan 5, 2019·Physical Review Letters·M AblikimUNKNOWN BESIII Collaboration

❮ Previous
Next ❯

Citations

Aug 28, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bo CaoDing-Kun Zhang
Nov 7, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xiao-Rong XuDing-Kun Zhang
Jan 30, 2021·International Journal of Analytical Chemistry·Hui JiangGaowa Jin
Apr 18, 2021·The Journal of Pharmacy and Pharmacology·Bo CaoLi Han

❮ Previous
Next ❯

Methods Mentioned

BETA
Fluorescence

Software Mentioned

Cytoscape
SPSS
SOFTmaxPRO
BinGo
Database Visualization and Integrated Discovery software ( DAVID
Metabo Analyst

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Related Papers

Annals of Oncology : Official Journal of the European Society for Medical Oncology
A FilipovicJ Stebbing
The Israel Medical Association Journal : IMAJ
F ContiG Valesini
© 2022 Meta ULC. All rights reserved