PMID: 362190Sep 1, 1978

Screening for the mutagenicity of nitro-group containing hypoxic cell radiosensitizers using Salmonella typhimurium strains TA 100 and TA98

Mutation Research
J B ChinA M Rauth

Abstract

A series of sixteen 2-, 4- and 5-nitroimidazoles, four nitrobenzenes, five nitrofurans, and a nitropyrrole, most of which have been studied previously as hypoxic cell specific radiosensitizers, have been screened for their mutagenicity using the Salmonella typhimurium strains TA 100 and TA 98 developed by Ames and co-workers. Most of these compounds were mutagenic and had a one to two order of magnitude greater mutagenicity towards TA 100 (base-pair substitution sensitive) than TA 98 (frame-shift sensitive). The spectrum of mutagenic efficiencies for the drugs which was observed could be correlated to some extent with the electron affinity of these compounds. Exceptions to this correlation may indicate drugs of interest for further studies both as mutagens and hypoxic cell radiosensitizers.

References

Oct 1, 1975·Canadian Journal of Microbiology·D R McCallaM L Fan
May 1, 1977·Biochemical Pharmacology·H S Rosenkranz
Jun 1, 1976·Mutation Research·H S RosenkranzJ E Stambaugh
Sep 1, 1976·Antimicrobial Agents and Chemotherapy·D G Lindmark, M Müller
Oct 4, 1976·Biochemical and Biophysical Research Communications·G E AdamsM E Watts
Dec 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J MccannB N Ames
Feb 1, 1975·Mutation Research·D R McCallaP L Olive
Jun 1, 1975·Mutation Research·C E VoogdJ J Jacobs
Sep 16, 1975·Biochemical and Biophysical Research Communications·H S Rosenkranz, W T Speck
Jan 1, 1973·Annual Review of Microbiology·E Grunberg, E H Titsworth
Feb 1, 1974·Mutation Research·D R McCalla, D Voutsinos

Citations

Feb 1, 1986·Toxicology and Applied Pharmacology·J C GreenawayM R Juchau
Jun 1, 1994·Mutation Research·L DobiásR Srám
Jan 1, 1985·Molecular and Biochemical Parasitology·N YarlettM Müller
Jan 1, 1983·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·M Agosin
Jan 1, 1989·International Journal of Radiation Applications and Instrumentation. Part A, Applied Radiation and Isotopes·D R HwangM J Welch
Jun 8, 2002·Mutation Research·Andrés BendeskyP Ostrosky-Wegman
Nov 20, 1980·The New England Journal of Medicine·J Koch-Weser, P Goldman
Oct 1, 1980·Antimicrobial Agents and Chemotherapy·E J ChrystalP Goldman
Sep 1, 1985·Environmental Health Perspectives·C F Chignell
Dec 1, 1985·Environmental Health Perspectives·S N Moreno, R Docampo
Feb 1, 1981·The British Journal of Radiology·C Michel, H Fritz-Niggli
Apr 1, 1980·The British Journal of Radiology·J S Prosser, L C Hesketh
Apr 1, 1980·The British Journal of Radiology·T Alper
Jan 24, 2006·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·S F FreitasS Guimarães
Jan 1, 1983·Teratogenesis, Carcinogenesis, and Mutagenesis·G L BiagiP A Borea
Jan 1, 1983·Teratogenesis, Carcinogenesis, and Mutagenesis·G Cantelli-FortiG L Biagi
Apr 1, 1983·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·I R RowlandE Bailey
Jun 24, 2010·Critical Reviews in Toxicology·Gail T ArcePramila Singh

Related Concepts

Medicinal Plants Testing, Preclinical
Genetic Techniques
Clastogens
Nitrated Compounds
Nitrobenzenes
Nitrofurans
Nitroimidazoles
Pyrroles
Radiation-Sensitizing Effect
Salmonella typhimurium LT2

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.