Screening for viral nucleic acids in vestibular schwannoma

Journal of Neurovirology
Aril Løge HåvikPer-Morten Knappskog

Abstract

To investigate if viruses are involved in the pathogenesis of vestibular schwannomas (VS), we have screened biopsies from VS patients using different molecular techniques. Screening for the presence of known viruses using a pan-viral microarray assay (ViroChip) indicated the presence of several viruses including human endogenous retrovirus K (HERV-K) and human herpes virus 2 (HHV2). But with the exception of HERV-K, none of the findings could be verified by other methods. Whole transcriptome sequencing showed only the presence of HERV-K transcripts and whole genome sequencing showed only the presence of Epstein-Barr virus, most likely originating from infiltration of lymphocytes. We therefore conclude that it is less likely that viruses are involved in the pathogenesis of vestibular schwannomas.

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Citations

Apr 19, 2019·Ear and Hearing·Lisa AarhusBo Engdahl
Jul 3, 2021·Journal of Neuro-oncology·Peter Taule-SivertsenPer Morten Knappskog

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Methods Mentioned

BETA
Gamma Knife
amputation
electrophoresis
PCR
biopsies
RNAseq
Gamma Knife Radiosurgery

Software Mentioned

Predict
HudsonAlpha
bowtie2
Virochip
samtools
Integrative Genomics Viewer ( IGV )

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