Screening for Zinc Deficiency in Patients with Cirrhosis: When Should We Start?

Digestive Diseases and Sciences
Shreya SenguptaHelen Te

Abstract

Zinc deficiency has been observed in cirrhosis, but management guidelines do not address screening for zinc deficiency. We aim to determine the prevalence of zinc deficiency in different stages of cirrhosis and to correlate zinc levels with complications of cirrhosis and clinical outcomes. Patients who had a diagnosis of cirrhosis and had serum zinc levels drawn from 2007 to 2011 were identified. Demographics, laboratory data, presence of ascites, encephalopathy, and infection were obtained; Child-Pugh and MELD scores were calculated. Stata software was used for data analysis. A total of 163 patients were included in the study. The median serum zinc level was 0.47 mcg/ml (IQR 0.37-0.63); 83 % of patients were zinc deficient. Zinc deficiency was more prevalent in patients with Child-Pugh score B or C, and with MELD scores ≥15. Zinc levels were lower in alcoholic, hepatitis C, and cholestatic diseases than in other etiologies of liver disease. Zinc levels correlated with INR (r = -0.56, p < 0.001), bilirubin (r = -0.51, p < 0.001), and albumin (r = 0.68, p < 0.001), and were lower in patients with ascites (0.40 vs. 0.57 mcg/ml, p < 0.001), encephalopathy (0.40 vs. 0.53 mcg/ml, p < 0.001), diuretic use (0.45 vs. 0.535 mcg/ml, p = ...Continue Reading

References

Jan 1, 1976·Bioinorganic Chemistry·E L GirouxP J Schechter
Mar 31, 1976·European Journal of Clinical Investigation·P J SchechterA Sjoerdsma
Jan 1, 1978·The American Journal of the Medical Sciences·R D LindemanS Kraikitpanitch
Jan 1, 1986·The British Journal of Nutrition·P S DowdP J Guillou
Sep 1, 1988·Digestive Diseases and Sciences·S KarayalcinO Uzunalimoglu
Apr 1, 1985·Digestive Diseases and Sciences·L S ValbergM J Chamberlain
Jul 1, 1980·Gut·P W KeelingR P Thompson
Mar 1, 1994·European Journal of Clinical Investigation·E RocchiG Casalgrandi
Aug 13, 1998·The American Journal of Clinical Nutrition·A H Shankar, A S Prasad
May 6, 2003·The Journal of Nutrition·Klaus-Helge Ibs, Lothar Rink
Nov 1, 1960·The Journal of Clinical Investigation·R E FREDRICKSW N VALENTINE
Jun 11, 2004·Annual Review of Nutrition·Pamela J Fraker, Louis E King
Jul 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Koki KabuToshio Hirano
Apr 7, 2007·Digestive Diseases and Sciences·Ioannis StamoulisStamatios Theocharis
Oct 13, 2009·Journal of Gastroenterology and Hepatology·Perlina Umusig-Quitain, Germana V Gregorio
Sep 9, 2010·Alimentary Pharmacology & Therapeutics·Y TakumaH Takahashi
Nov 15, 2011·Molecular Nutrition & Food Research·Carmen P Wong, Emily Ho

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Citations

Feb 24, 2016·Journal of Hepatology·Johannes WiegandThomas Berg
Sep 1, 2015·Digestive Diseases and Sciences·Sasha MangrayPuneet Puri
Oct 26, 2018·Brain and Behavior·Hirofumi MatsuyamaHidekazu Tomimoto
Nov 7, 2019·European Journal of Gastroenterology & Hepatology·Takanori ItoMitsuhiro Fujishiro
Mar 14, 2019·Journal of Clinical Medicine·Hiroki NishikawaShuhei Nishiguchi
Jan 21, 2021·Biological Trace Element Research·Stefan RodicCarl van Walraven
May 1, 2021·Nutrients·Gemma Llibre-NietoJordi Sánchez-Delgado
Jul 8, 2021·Clinics in Liver Disease·Craig J McClainLuis S Marsano
Nov 12, 2021·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Norifumi HarimotoKen Shirabe

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