Screening instrument to identify skin prick test-negative patients with asthma and/or rhinitis

The Clinical Respiratory Journal
Ebru CelebiogluA F Kalyoncu

Abstract

To the best of our knowledge, there is no prediction tool for determining respiratory allergy in patients with asthma and/or rhinitis. As such, this study aimed to develop an instrument for identifying skin prick test (SPT)-negative patients with asthma and/or rhinitis. This cross-sectional study screened 510 consecutive patients diagnosed with asthma and/or rhinitis between November 2009 and May 2011 in Ankara, Turkey. A structured questionnaire was the screening tool that was administered during the initial visit by the treating specialist and compared with a SPT result. All 15 variables were analysed using the logistic regression model to obtain β values (a score) for each variable. Each variable had a score, and scores were summed up to obtain final score for each patient. The study included 363 patients, of which 165 (45.5%) were SPT positive. The final model included 13 variables. The lowest and highest scores were -21 and 26. A total score of 5.5 had sensitivity of 63% and specificity of 80%. The area under the receiver operating characteristic curve was 0.78. The histogram of the total scores for the study population was bimodal. We designed a highly specific 13-item instrument for identifying SPT-negative patients. It ...Continue Reading

References

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Oct 19, 2010·Indian Journal of Ophthalmology·Rajeev Kumar Malhotra, A Indrayan
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Apr 15, 2011·Allergologia et immunopathologia·G KarakayaA F Kalyoncu
Nov 5, 2011·Allergy·J BousquetUNKNOWN Allergic Rhinitis and its Impact on Asthma

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