PMID: 16646468May 2, 2006Paper

Screening level risk assessment model for chemical fate and effects in the environment

Environmental Science & Technology
Jon A ArnotJeanette M Southwood

Abstract

A screening level risk assessment model is developed and described to assess and prioritize chemicals by estimating environmental fate and transport, bioaccumulation, and exposure to humans and wildlife for a unit emission rate. The most sensitive risk endpoint is identified and a critical emission rate is then calculated as a result of that endpoint being reached. Finally, this estimated critical emission rate is compared with the estimated actual emission rate as a risk assessment factor. This "back-tracking" process avoids the use of highly uncertain emission rate data as model input. The application of the model is demonstrated in detail for three diverse chemicals and in less detail for a group of 70 chemicals drawn from the Canadian Domestic Substances List. The simple Level II and the more complex Level III fate calculations are used to "bin" substances into categories of similar probable risk. The essential role of the model is to synthesize information on chemical and environmental properties within a consistent mass balance framework to yield an overall estimate of screening level risk with respect to the defined endpoint. The approach may be useful to identify and prioritize those chemicals of commerce that are of gr...Continue Reading

References

Aug 1, 1987·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·R L LipnickA K Strausz
Jan 1, 1994·SAR and QSAR in Environmental Research·H J VerhaarJ L Hermens
Apr 15, 2004·Chemosphere·Eva WebsterDavid Woodfine
Aug 7, 2004·Environmental Science & Technology·Valérie MaederKonrad Hungerbühler
Oct 30, 2004·Environmental Toxicology and Chemistry·Matthew MacLeod, Thomas E McKone

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Citations

Jun 14, 2013·Environmental Science & Technology·John F WambaughElaine A Cohen Hubal
May 28, 2013·The Science of the Total Environment·Jade MitchellDaniel A Vallero
Aug 15, 2015·Integrated Environmental Assessment and Management·Frank A P C GobasJose V Tarazona
Jul 16, 2014·The Science of the Total Environment·Maja KuzmanovićDamia Barceló
Sep 14, 2010·Environment International·N Musee
Jun 26, 2010·Journal of Hazardous Materials·Mohammad A BatihaAbu Bakar Mohamad
Apr 5, 2008·Journal of Molecular Graphics & Modelling·Ester Papa, Paola Gramatica
Aug 8, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Barbara A WetmoreMelvin E Andersen
Sep 14, 2010·Integrated Environmental Assessment and Management·Don MackayRobert E Bailey
Sep 8, 2010·Environmental Toxicology and Chemistry·Jon A ArnotChristopher S Warren
Sep 10, 2014·Environmental Science & Technology·Koki TakakiChris D Collins
Apr 13, 2015·Environmental Research·Shizhen ZhaoAndrew J Sweetman
Aug 19, 2007·Environmental Pollution·Rainer LohmannDerek Muir
Sep 22, 2016·Environmental and Molecular Mutagenesis·Kerry L DearfieldMirjam Luijten
Mar 20, 2018·Environmental Science. Processes & Impacts·Michael S McLachlanMatthew MacLeod
Dec 31, 2017·Journal of Exposure Science & Environmental Epidemiology·Jon R SobusSeth R Newton
Mar 30, 2016·Environmental Science and Pollution Research International·Kieran O'DriscollRory Doherty
May 4, 2012·Environmental Monitoring and Assessment·Veerasingam Armugam Santhi, Ali Mohd Mustafa
Jul 29, 2011·Environmental Toxicology and Chemistry·Eva M Webster, David A Ellis
Apr 9, 2015·Diseases of Aquatic Organisms·Zahra KhoshnoodSaber Khodabandeh
Jan 11, 2018·Environmental Science. Processes & Impacts·Antonio Di GuardoMartin Scheringer
Jul 5, 2012·Environmental Toxicology and Chemistry·Eva M Webster, David A Ellis
Mar 8, 2017·Critical Reviews in Toxicology·M DellarcoJ Y Tanir
Jul 13, 2012·Journal of Environmental Monitoring : JEM·Knut BreivikFrank Wania
Dec 23, 2017·Environmental Science. Processes & Impacts·Mark A BonnellDon Gutzman
May 8, 2018·The Science of the Total Environment·Chantel I NicolasJohn F Wambaugh
Oct 2, 2017·The Science of the Total Environment·Cory L StropeJohn F Wambaugh
Dec 22, 2006·Environmental Science & Technology·Derek C G Muir, Philip H Howard
Aug 14, 2010·Environmental Science & Technology·Emma UndemanMichael S McLachlan
Sep 30, 2014·Environmental Science & Technology·Xianming ZhangFrank Wania
Jul 18, 2018·Environmental Science & Technology·Michel LavoieWarwick F Vincent

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