Screening of a natural compound library identifies emodin, a natural compound from Rheum palmatum Linn that inhibits DPP4

PeerJ
Zhaokai WangMin Li

Abstract

Historically, Chinese herbal medicines have been widely used in the treatment of hyperglycemia, but the mechanisms underlying their effectiveness remain largely unknown. Here, we screened a compound library primarily comprised of natural compounds extracted from herbs and marine organisms. The results showed that emodin, a natural compound from Rheum palmatum Linn, inhibited DPP4 activity with an in vitro IC50 of 5.76 µM without inhibiting either DPP8 or DPP9. A docking model revealed that emodin binds to DPP4 protein through Glu205 and Glu206, although with low affinity. Moreover, emodin treatment (3, 10 and 30 mg/kg, P.O.) in mice decreased plasma DPP4 activity in a dose-dependent manner. Our study suggests that emodin inhibits DPP4 activity and may represent a novel therapeutic for the treatment of type 2 diabetes.

References

Jan 1, 1966·Histochemie. Histochemistry. Histochimie·V K Hopsu-Havu, G G Glenner
Feb 14, 1998·Current Microbiology·H H Wang, J G Chung
Aug 2, 2003·Critical Reviews in Clinical Laboratory Sciences·Anne-Marie LambeirIngrid De Meester
Jul 22, 2004·The Cochrane Database of Systematic Reviews·J P LiuS Grimsgaard
May 15, 2007·Gastroenterology·Laurie L Baggio, Daniel J Drucker
Sep 13, 2008·Clinical and Experimental Pharmacology & Physiology·Xiao-Yan ZhaoBao-Feng Yang
Jun 4, 2010·Journal of Natural Products·Wei-Jan HuangFen-Lin Hsu
Jan 6, 2011·Diabetes, Obesity & Metabolism·W Xie, L Du
Aug 18, 2012·Food & Function·Hsiu-Ju Wang, Been-Huang Chiang
Jan 11, 2013·The Journal of Biological Chemistry·Parkyong SongSung Ho Ryu
Jan 18, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yan GengZheng-Hong Xu
Sep 27, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Junfeng FanElvira Gonzalez de Mejia
Jun 28, 2014·Archives of Pharmacal Research·Ya-Jun LinYong-Zhan Zhen
Sep 13, 2014·Endocrine Reviews·Erin E Mulvihill, Daniel J Drucker
Sep 19, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhiqin WuWei Deng
Mar 21, 2015·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Tingfang ChenNiansong Wang

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Citations

Jan 30, 2019·International Journal of Molecular Sciences·Po-Kai HuangChing-Feng Weng
Feb 17, 2018·Neural Regeneration Research·Ghaith Al-BadriAlessandro Castorina
Nov 28, 2019·Phytotherapy Research : PTR·Aminu MohammedMurtala Bindawa Isah
Aug 29, 2020·Natural Product Reports·Jeffrey A van SantenRoger G Linington
Sep 27, 2019·Therapeutic Advances in Chronic Disease·Shian-Ren LinChing-Feng Weng
May 19, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Beida RenQingguo Wang
Jul 11, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lebin WengChing-Feng Weng

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