Screening of antidiabetic and antioxidant activities of medicinal plants

Journal of Integrative Medicine
Amal Bakr Shori

Abstract

Diabetes is a common metabolic disorder characterized by abnormally increased plasma glucose levels. Postprandial hyperglycemia plays an essential role in development of type-2 diabetes. Inhibitors of carbohydrate-hydrolyzing enzymes (such as α-glucosidase and α-amylase) offer an effective strategy to regulate/prevent hyperglycemia by controlling starch breakdown. Natural α-amylase and α-glucosidase inhibitors, as well as antioxidants from plant-based sources, offer a source of dietary ingredients that affect human physiological function in order to treat diabetes. Several research studies have investigated the effectiveness of plant-based inhibitors of α-amylase and α-glucosidase, as well as their antioxidant activity. The aim of this review is to summarize the antidiabetic and antioxidant properties of several medicinal plants around the world. Half inhibitory concentration (IC50, for enzyme suppression) and half effective concentration (EC50, for antioxidant activity) values of less than 500 μg/mL were defined as the most potent plant-based inhibitors (in vitro) and are expected to provide interesting candidates for herbal treatment of diabetes, as foods, supplements, or refined drugs.

References

Sep 5, 2002·Journal of Agricultural and Food Chemistry·V ExarchouD Boskou
Apr 23, 2003·Journal of the American College of Cardiology·Marcelo F Di CarliJoel Ager
May 10, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Z Sroka, W Cisowski
Sep 29, 2004·Diabetes Care·Wolfgang Rathmann, Guido Giani
Jan 19, 2005·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Alice Y Y Cheng, I George Fantus
Jan 27, 2005·Drugs·Andrew J Krentz, Clifford J Bailey
Aug 6, 2005·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Roja RahimiMohammad Abdollahi
Feb 23, 2010·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·T PsaltopoulouC Stefanadis
Jan 22, 2011·BMC Complementary and Alternative Medicine·Sudha PAmeeta R Kumar
Oct 19, 2011·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Adedayo O Ademiluyi, Ganiyu Oboh
Feb 26, 2013·Journal of Acupuncture and Meridian Studies·Ellappan ThilagamSubhash Chandra Mandal
Apr 10, 2013·Journal of Ethnopharmacology·Luo-sheng WanJiachun Chen
Jun 26, 2013·Food Chemistry·Kannan R R RengasamyJohannes Van Staden
Jul 23, 2013·Food Chemistry·Sinéad LordanR Paul Ross

❮ Previous
Next ❯

Citations

Feb 24, 2016·Future Medicinal Chemistry·Kenneth Lundstrom
Aug 4, 2016·Naunyn-Schmiedeberg's Archives of Pharmacology·Ho-Shan NiuJuei-Tang Cheng
Jun 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mi Jin Park, Young-Hwa Kang
Apr 18, 2019·BioMed Research International·Gabriela PaunGabriel Lucian Radu
Sep 19, 2020·Journal of Experimental Pharmacology·Muluken Altaye AyzaAbera Hadgu Berhe
Jul 22, 2017·Frontiers in Pharmacology·Ajda Ota, Nataša P Ulrih
Dec 31, 2016·Nutrition and Healthy Aging·Rachel A BrewerDaniel L Smith
Sep 21, 2017·Medicines·Kenneth LundstromLong Doan Dinh
Apr 25, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Muluken Altaye AyzaAbera Hadgu Berhe
Jan 27, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Renner Philipe Rodrigues CarvalhoMariana Machado-Neves
Feb 11, 2021·Plants·Clarissa Marcelle NaidooNasser Al-Suhaibani

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

BMC Complementary and Alternative Medicine
Sudha PAmeeta R Kumar
Iranian Journal of Pharmaceutical Research : IJPR
Bahman Nickavar, Gholamreza Amin
Advances in Food and Nutrition Research
Hongyu WangDejian Huang
© 2021 Meta ULC. All rights reserved