Screening of cancer tissue arrays identifies CXCR4 on adrenocortical carcinoma: correlates with expression and quantification on metastases using (64)Cu-plerixafor PET

Oncotarget
Ido D WeissJoshua M Farber

Abstract

Expression of the chemokine receptor CXCR4 by many cancers correlates with aggressive clinical behavior. As part of the initial studies in a project whose goal was to quantify CXCR4 expression on cancers non-invasively, we examined CXCR4 expression in cancer samples by immunohistochemistry using a validated anti-CXCR4 antibody. Among solid tumors, we found expression of CXCR4 on significant percentages of major types of kidney, lung, and pancreatic adenocarcinomas, and, notably, on metastases of clear cell renal cell carcinoma and squamous cell carcinoma of the lung. We found particularly high expression of CXCR4 on adrenocortical cancer (ACC) metastases. Microarrays of ACC metastases revealed correlations between expression of CXCR4 and other chemokine system genes, particularly CXCR7/ACKR3, which encodes an atypical chemokine receptor that shares a ligand, CXCL12, with CXCR4. A first-in-human study using (64)Cu-plerixafor for PET in an ACC patient prior to resection of metastases showed heterogeneity among metastatic nodules and good correlations among PET SUVs, CXCR4 staining, and CXCR4 mRNA. Additionally, we were able to show that CXCR4 expression correlated with the rates of growth of the pulmonary lesions in this patient....Continue Reading

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Citations

Oct 2, 2019·Cancer Biology & Therapy·Barbara MuzAbdel Kareem Azab
May 28, 2020·Cancers·Joseph LauXiaoyuan Chen
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Datasets Mentioned

BETA
GSE90713

Methods Mentioned

BETA
biopsies
gene array
surgical resection
Chips
flow cytometry

Clinical Trials Mentioned

NCT02069080
NCT02179970
NCT02737072
NCT02765165
NCT02015026

Software Mentioned

PrimeView
GOrilla
Capture
Affymetrix
GraphPad
MIM Encore
JMP Genomics
PACS
GraphPad Prism
MIM

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