Screening of celiac disease in children with Henoch-Schoenlein purpura

Rheumatology International
Alper SoyluSalih Kavukçu

Abstract

Prevalence of celiac disease (CD) is 2.42 % in healthy Turkish children. The frequency of IgA-associated disorders is increased in CD. Henoch-Schoenlein purpura (HSP) is an IgA-associated vasculitis. Association of HSP with CD has not been evaluated. We aimed to evaluate whether CD prevalence is increased in children with HSP. Children with HSP were evaluated for demographic, anthropometric, clinical, and laboratory data including urinalysis, complete blood count, albumin, creatinine, and IgA levels. In addition, tTG-IgA, EMA-IgA, anti-DGP-IgA, and IgG antibody levels were measured. Seropositive patients were evaluated by endoscopic small bowel biopsy. The rate of CD seropositivity and confirmed CD in HSP patients was compared to the rate in healthy Turkish children. There were 42 children (25 male) with HSP. No patient had classical CD symptoms, but two patients had growth failure. None of them had IgA deficiency, anemia or hypoalbuminemia. Celiac serology was positive in five (12 %) children. Endoscopic evaluation was performed in four patients, and two (5 %) of them were confirmed to have CD. Prevalence of both CD seropositivity and histologically confirmed CD in children with HSP was significantly higher compared to healthy...Continue Reading

References

Sep 1, 1967·The American Journal of Digestive Diseases·H A Danemann, E C Texter
Jan 1, 1993·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·G WoodrowJ H Turney
Feb 7, 2001·The American Journal of Clinical Nutrition·E IsolauriS Salminen
Apr 19, 2003·Journal of Gastroenterology and Hepatology·Ashkan FarhadiAli Keshavarzian
Dec 6, 2003·The Journal of Pediatrics·Rocío MartínJuan M Rodríguez
Jul 28, 2005·Current Rheumatology Reports·Suzanne E LaneDavid G I Scott
Dec 3, 2005·Annals of the Rheumatic Diseases·S OzenP Woo
Jan 6, 2006·Kidney International·B D OortwijnC van Kooten
Jun 2, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Alper SoyluSalih Kavukçu
Sep 15, 2007·Autoimmunity Reviews·Ron Shaoul, Aaron Lerner
May 1, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Alper SoyluSalih Kavukçu
Apr 1, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hilde Kloster SmerudGudjón Kristjánsson
Aug 26, 2009·Journal of Gastroenterology and Hepatology·Adrian G Cummins, Ian C Roberts-Thomson
May 17, 2011·Journal of the American Academy of Dermatology·Manuel F LandechoJ Felipe Lucena
Jun 22, 2011·The American Journal of Gastroenterology·Buket DalgicUNKNOWN Turkish Celiac Study Group
May 3, 2012·Seminars in Immunopathology·Kimberly P Newton, Shereen A Singer
Jan 16, 2014·Autoimmunity Reviews·Yao-Hsu YangBor-Luen Chiang
Jul 30, 2014·Nature Reviews. Nephrology·Jean-Claude Davin, Rosanna Coppo

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