Screening of Combinatorial Quality Markers for Natural Products by Metabolomics Coupled With Chemometrics. A Case Study on Pollen Typhae

Frontiers in Pharmacology
Mingya DingYan-Xu Chang

Abstract

Natural products, especially for traditional Chinese medicines (TCMs), are of great importance to cure diseases. Yet it was hard to screen the influential quality markers for monitoring the quality. A simple and comprehensive strategy was developed and validated to screen for the combinatorial quality markers for precise quality evaluation and discrimination of natural products. In this study, Pollen Typhae (PT) and it's processed products carbonized PT were selected as the representative case. Firstly, metabolomics data of 49 batches crude PT and carbonized PT was obtained by ultra high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF/MS). Then, metabolomics approaches were performed to screen for the potential markers that lead to the quality difference. Finally, chemometric methods were used to validate the accuracy of combinatorial quality markers. Thus, 42 compounds were identified from PT, 5 markers (isorhamnetin-3-O-(2G-α-L-rhamnosyl)-rutinoside, isorhamnetin-3-O-neohesperidoside, astragalin, kaempferol and umbelliferone) were successfully screened, identified, quantified and regarded as combinatorial quality markers for precise quality evaluation of crude and carbon...Continue Reading

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Citations

Mar 21, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhijun WuHong Wang
Jun 9, 2020·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Xiaoyan WangYan-Xu Chang
Aug 20, 2021·Cellular and Molecular Life Sciences : CMLS·Andrey S MarchevMilen I Georgiev

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Software Mentioned

Matlab
SPSS
R package
Simca
R Foundation for Statistical Computing
XCMS

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