Screening of concentrations of C-reactive protein and various plasma protease inhibitors preoperatively for the prediction of postoperative complications

The European Journal of Surgery = Acta Chirurgica
J GöranssonA Lasson

Abstract

To find out whether concentrations of albumin (reflecting nutritional state), C-reactive protein (reflecting an acute phase reaction) or plasma protease inhibitors (reflecting ongoing proteolysis) are good predictors of postoperative complications, and whether other biochemical tests may improve diagnostic accuracy. Retrospective study. University hospital, Sweden. 260 patients undergoing elective surgery for malignant (n = 149) or benign (n = 111) disease. Preoperative biochemical plasma measurements and postoperative complications. 192 patients recovered uneventfully and 35 had minor and 33 major postoperative complications. An increased plasma C-reactive protein concentration preoperatively, as well as a reduced albumin concentration, predicted the risk of developing major postoperative complications. Measurement of plasma protease inhibitors (C1-esterase inhibitor, alpha-2-macroglobulin and antithrombin III), specific biochemical studies of microheterogeneity, or comparison of quantitative and functional concentrations of the inhibitors gave no additional information. One measurement of the C-reactive protein and albumin concentrations preoperatively will identify patients at risk of developing severe postoperative complica...Continue Reading

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