Screening of differentially expressed genes in male idiopathic osteoporosis via RNA sequencing

Molecular Medicine Reports
Li FengBo Xia

Abstract

As a type of osteoporosis (OP), male idiopathic OP (MIO) is a bone disorder that occurs in young males and is a public health problem worldwide. However, the detailed pathogenesis of MIO remains to be elucidated. In the present study, blood samples of patients with MIO, senile OP, postmenopausal OP and normal controls (NCs) were obtained for RNA sequencing. Compared with the NC group, differentially expressed genes (DEGs) in the three types of OP were identified. DEGs that were common among the three types of OP and the DEGs that were unique to patients with MIO were determined. Gene ontology enrichment analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses were conducted. MIO‑specific and OP‑specific protein‑protein interaction (PPI) networks were constructed. Compared with NCs, a total of 519, 368 and 1,472 DEGs were identified in samples from MIO, senile OP and postmenopausal OP, respectively. Tetraspanin 5 (TSPAN5) and α‑synuclein (SNCA) were unique DEGs in MIO that were not identified in the other two types of OP compared with NCs. Furthermore, the expression of carbonic anhydrase 1 (CA1) and S100 calcium‑binding protein P (S100P) in MIO was significantly different compared with senile OP, postmen...Continue Reading

References

Jul 25, 2003·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Susan B JaglalDave Davis
Jan 19, 2010·Biochimica Et Biophysica Acta·Eun Kyung Kim, Eui-Ju Choi
Mar 5, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Imranul AlamCharles H Turner
Dec 15, 2010·BMC Musculoskeletal Disorders·Xiaotian ChangYazhou Cui
Feb 11, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Janina M PatschPeter Pietschmann
Mar 15, 2011·Best Practice & Research. Clinical Endocrinology & Metabolism·Evelien GielenSteven Boonen
Aug 2, 2011·Joint, Bone, Spine : Revue Du Rhumatisme·Julien PaccouBernard Cortet
May 11, 2012·Nucleic Acids Research·Daniel Tabas-MadridAlberto Pascual-Montano
Nov 15, 2013·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Do Yeon KimSung Hyun Chung
Feb 27, 2014·Current Drug Targets·Princi JainPiyush Trivedi
Jun 18, 2014·Calcified Tissue International·Jian ZhouHaibo Zhao
Aug 29, 2014·F1000Research·Barry DemchakJill P Mesirov
Jan 15, 2015·Journal of Biomechanics·Jenneke Klein-NulendRommel G Bacabac
Jan 18, 2015·The Journal of Biological Chemistry·Ali Hashemi GheinaniKatia Monastyrskaya
Apr 26, 2015·Calcified Tissue International·Christian MuschitzPeter Pietschmann
Jul 23, 2016·Nature Reviews. Rheumatology·David KarasikMark L Johnson

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Cuffdiff
FastQC
TopHat
Cuffquant
cutadapt
gplots
R
Cytoscape
GeneCodis
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