Screening of differentially expressed microRNAs of essential hypertension in Uyghur population.

Lipids in Health and Disease
Yuanzheng YeBaopeng Tang

Abstract

Essential hypertension can cause many kinds of cardiovascular diseases. The pathogenesis of essential hypertension is very complex, and the mechanism is still unclear. The microRNAs have been identified as novel biomarkers for pre-diagnosis and prognosis of hypertension. However, the kinds of microRNAs that can be used as specific biomarkers for hypertension are unknown. Plasma samples were isolated from Uyghur subjects with essential hypertension and the healthy individuals. Microarray was used to identify differentially expressed microRNAs. The microarray data were clustered and annotated with online software. The target genes of differentially expressed microRNAs were also analyzed. The microarray results were further verified by quantitative real-time PCR. We identified 257 microRNAs that were differentially expressed between patients with essential hypertension and the healthy individuals. These microRNAs had a total of 6580 target genes. The 47 microRNAs that had target genes, including 24 up-regulated and 23 down-regulated microRNAs, were further screened out to construct a reference set of potential microRNA biomarkers. Most of the 47 microRNAs were located at chromosome 19 (40 microRNAs) and chromosome 1 (45 microRNAs)...Continue Reading

References

Jul 14, 2010·Biochimica Et Biophysica Acta·Fazli WahidYou Young Kim
Apr 19, 2012·Nature Reviews. Molecular Cell Biology·Maria Mittelbrunn, Francisco Sánchez-Madrid
Sep 22, 2012·Current Hypertension Reports·Vanessa P M van EmpelPaula A da Costa Martins
May 6, 2014·Journal of the American Society of Hypertension : JASH·Joanna E KontarakiPanos E Vardas
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Apr 15, 2015·Vascular Pharmacology·Costanza EmanueliSusmita Sahoo
Sep 1, 2015·Molecular Medicine·Francine Z MarquesMaciej Tomaszewski

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Citations

Oct 20, 2019·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Vijayashree Priyadharsini Jayaseelan, Paramasivam Arumugam
Nov 19, 2019·Frontiers in Endocrinology·Abel DecmannPeter Igaz
Feb 13, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Paulina Pei Suu TanYuh-Fen Pung

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Methods Mentioned

BETA
PCR
Feature Extraction
AGT

Software Mentioned

Targetscan
GraphPad
Genespring
microRNAorg
Feature Extraction
DAVID
Prism
PITA

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